PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26542288-0 2015 Betulinic acid downregulates expression of oxidative stress-induced lipoprotein lipase via the PKC/ERK/c-Fos pathway in RAW264.7 macrophages. betulinic acid 0-14 mitogen-activated protein kinase 1 Homo sapiens 99-102 31344390-13 2019 The BA analogues H3, H5 and H7 are protective against glutamate-induced oxidative stress in human Muller cells, and elicit their actions by modulation of the Erk, Akt and JNK signaling pathways. betulinic acid 4-6 mitogen-activated protein kinase 1 Homo sapiens 158-161 21077850-5 2011 EXPERIMENTAL APPROACH: We determined the ability of BA to interfere with p38 and extracellular regulated kinase (ERK) phosphorylation as well as Akt phosphorylation and nuclear factor-kappaB activation using LPS-activated hPBMCs as an in vitro model. betulinic acid 52-54 mitogen-activated protein kinase 1 Homo sapiens 73-76 25418122-8 2015 RESULTS: In this study, results show that triggering TGR5 with the specific agonist betulinic acid (BA), and the bile acids CDCA or DCA, activated both the main MAP kinases ERK1/2, p38 and JNK, and the NF-kappaB signaling pathway. betulinic acid 84-98 mitogen-activated protein kinase 1 Homo sapiens 181-184 25418122-8 2015 RESULTS: In this study, results show that triggering TGR5 with the specific agonist betulinic acid (BA), and the bile acids CDCA or DCA, activated both the main MAP kinases ERK1/2, p38 and JNK, and the NF-kappaB signaling pathway. betulinic acid 100-102 mitogen-activated protein kinase 1 Homo sapiens 181-184 21077850-7 2011 KEY RESULTS: BA inhibited LPS-induced COX-2 protein expression and prostaglandin E(2) production and also attenuated LPS-induced ERK and Akt phosphorylation, but not p38 in hPBMCs. betulinic acid 13-15 mitogen-activated protein kinase 1 Homo sapiens 166-169 21077850-5 2011 EXPERIMENTAL APPROACH: We determined the ability of BA to interfere with p38 and extracellular regulated kinase (ERK) phosphorylation as well as Akt phosphorylation and nuclear factor-kappaB activation using LPS-activated hPBMCs as an in vitro model. betulinic acid 52-54 mitogen-activated protein kinase 1 Homo sapiens 81-111 21077850-5 2011 EXPERIMENTAL APPROACH: We determined the ability of BA to interfere with p38 and extracellular regulated kinase (ERK) phosphorylation as well as Akt phosphorylation and nuclear factor-kappaB activation using LPS-activated hPBMCs as an in vitro model. betulinic acid 52-54 mitogen-activated protein kinase 1 Homo sapiens 113-116 21077850-7 2011 KEY RESULTS: BA inhibited LPS-induced COX-2 protein expression and prostaglandin E(2) production and also attenuated LPS-induced ERK and Akt phosphorylation, but not p38 in hPBMCs. betulinic acid 13-15 mitogen-activated protein kinase 1 Homo sapiens 129-132 16077934-9 2005 AKT activation started 15 min post-treatment, peaked at approximately 1 h, remained elevated for 4 h and returned to basal level within 8 h. BA also induced ERK activation and, in contrast, weakly induced JNK and p38 activation. betulinic acid 141-143 mitogen-activated protein kinase 1 Homo sapiens 157-160 16152620-9 2006 Our data show for the first time that (a) cdk4 protein is an early target of betulinic acid-induced apoptosis and (b) unrestricted ERK signaling favours betulinic acid-induced apoptosis, but this is counteracted by U0126, partly through counteracting chromatin condensation and restoring Akt activation decreased by betulinic acid treatment. betulinic acid 153-167 mitogen-activated protein kinase 1 Homo sapiens 131-134 16152620-9 2006 Our data show for the first time that (a) cdk4 protein is an early target of betulinic acid-induced apoptosis and (b) unrestricted ERK signaling favours betulinic acid-induced apoptosis, but this is counteracted by U0126, partly through counteracting chromatin condensation and restoring Akt activation decreased by betulinic acid treatment. betulinic acid 153-167 mitogen-activated protein kinase 1 Homo sapiens 131-134 16077934-10 2005 Pretreatment of EGFR inhibitor PD153035 blocked BA-induced EGFR phosphorylation, ERK and AKT activation, and survivin expression. betulinic acid 48-50 mitogen-activated protein kinase 1 Homo sapiens 81-84 32842569-7 2020 Besides, BA downregulated the phosphorylation of the p38, JNK, and ERK proteins, while it upregulated the expression of the Nrf2 and HO-1 proteins in thymus tissues. betulinic acid 9-11 mitogen-activated protein kinase 1 Homo sapiens 67-70 34860480-0 2021 Betulinic acid targets drug-resistant human gastric cancer cells by inducing autophagic cell death, suppresses cell migration and invasion, and modulates the ERK/MEK signaling pathway. betulinic acid 0-14 mitogen-activated protein kinase 1 Homo sapiens 158-161 34860480-9 2021 Moreover, betulinic acid was observed to block the ERK/MEK signaling pathway in SGC-7901 cells, which was associated with declined levels of expressions of the phosphorylated ERK and MEK proteins. betulinic acid 10-24 mitogen-activated protein kinase 1 Homo sapiens 51-54 34860480-9 2021 Moreover, betulinic acid was observed to block the ERK/MEK signaling pathway in SGC-7901 cells, which was associated with declined levels of expressions of the phosphorylated ERK and MEK proteins. betulinic acid 10-24 mitogen-activated protein kinase 1 Homo sapiens 175-178 34860480-11 2021 In conclusion, these results demonstrated that betulinic acid exhibited significant anti-gastric cancer effects mediated via autophagy induction, blocking of ERK/MEK signaling and suppression of migration and invasion. betulinic acid 47-61 mitogen-activated protein kinase 1 Homo sapiens 158-161 34267658-0 2021 Combination Treatment With Inhibitors of ERK and Autophagy Enhances Antitumor Activity of Betulinic Acid in Non-small-Cell Lung Cancer In Vivo and In Vitro. betulinic acid 90-104 mitogen-activated protein kinase 1 Homo sapiens 41-44 34267658-4 2021 Mitogen-activated protein kinases, and especially ERK that facilitates cancer cell survival, are also activated by BA treatment. betulinic acid 115-117 mitogen-activated protein kinase 1 Homo sapiens 50-53 34267658-5 2021 As such, in the presence of ERK inhibitors (ERKi), lung cancer cells are much more sensitive to BA. betulinic acid 96-98 mitogen-activated protein kinase 1 Homo sapiens 28-31