PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31352642-0	2020	Betulinic acid attenuates lipopolysaccharide-induced vascular hyporeactivity in the rat aorta by modulating Nrf2 antioxidative function.	betulinic acid	0-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	108-112	
30125567-0	2018	Betulinic acid alleviates myocardial hypoxia/reoxygenation injury via inducing Nrf2/HO-1 and inhibiting p38 and JNK pathways.	betulinic acid	0-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	79-83	
28711658-0	2017	Betulinic acid, isolated from the leaves of Syzygium cumini (L.) Skeels, ameliorates the proteinuria in experimental membranous nephropathy through regulating Nrf2/NF-kappaB pathways.	betulinic acid	0-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	159-163	
28711658-8	2017	Furthermore, BA ameliorated mRNA and protein expression of NF-kappaB, iNOS, TNF-alpha, Nrf2, HO-1 and NQO1 in the kidney.	betulinic acid	13-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	87-91	
28711658-10	2017	In a nutshell, the protective effect of BA can be explained by its anti-inflammatory and anti-oxidant activities, which in turn is due to downregulation of NF-kappaB pathway and activation of Nrf2.	betulinic acid	40-42	NFE2 like bZIP transcription factor 2	Rattus norvegicus	192-196	
28711658-11	2017	The results indicated that BA can effectively suppress experimental PHN in rats by regulating Nrf2/NF-kappaB pathways.	betulinic acid	27-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-98	
30125567-7	2018	Besides, betulinic acid enhanced the activation of Nrf2/HO-1 pathway, and inhibited the activation of p38 and JNK pathways in H/R-induced H9c2 cells.	betulinic acid	9-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	51-55	
30125567-8	2018	Moreover, treatment with Nrf2 specific siRNA or the specific inhibitors of p38 and JNK attenuated the protective effects of betulinic acid on H9c2 cells.	betulinic acid	124-138	NFE2 like bZIP transcription factor 2	Rattus norvegicus	25-29	
28009869-10	2017	Furthermore, BA attenuated the phosphorylations of p-adenosine 5"-monophosphate-activated protein kinase (AMPK), nuclear factor kappaB (NF-kappaB), and an inhibitor of NF-kappaB (IkappaBalpha) and the expressions of NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO)-1.	betulinic acid	13-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	216-238	
28009869-10	2017	Furthermore, BA attenuated the phosphorylations of p-adenosine 5"-monophosphate-activated protein kinase (AMPK), nuclear factor kappaB (NF-kappaB), and an inhibitor of NF-kappaB (IkappaBalpha) and the expressions of NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO)-1.	betulinic acid	13-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	240-244	
28009869-11	2017	These findings demonstrated that BA exhibited a protective effect on diabetic nephropathy in STZ-induced rats possibly through the AMPK/NF-kappaB/Nrf2 pathway.	betulinic acid	33-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	146-150	
31352642-14	2020	These findings suggest that BA attenuates impairments of aortic contraction and relaxation in LPS-challenged rats by activating Nrf2-regulated antioxidative pathways.	betulinic acid	28-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	128-132