PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21971413-0	2011	Rottlerin enhances IL-1beta-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells.	rottlerin	0-9	interleukin 1 beta	Homo sapiens	19-27	
12732207-9	2003	The only inhibitor that was able to block IL-1beta- and TNFalpha-induced nephrin upregulation was rottlerin, which has been suggested to act as a selective PKCdelta inhibitor.	rottlerin	98-107	interleukin 1 beta	Homo sapiens	42-50	
11274209-6	2001	This regulation of NF-kappaB activation by PKCdelta was specific only for TNFalpha signaling, since lipopolysaccharide- or interleukin-1beta-induced NF-kappaB activation and IkappaBalpha degradation were not inhibited by rottlerin.	rottlerin	221-230	interleukin 1 beta	Homo sapiens	123-140	
21971413-9	2011	Taken together, our results suggest that rottlerin causes IL-1beta-induced COX-2 upregulation through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells.	rottlerin	41-50	interleukin 1 beta	Homo sapiens	58-66	
21971413-2	2011	In this study, we investigated the underlying molecular mechanism of the synergistic effect of rottlerin on interleukin1beta (IL-1beta)-induced COX-2 expression in MDA-MB-231 human breast cancer cell line.	rottlerin	95-104	interleukin 1 beta	Homo sapiens	108-124	
21971413-2	2011	In this study, we investigated the underlying molecular mechanism of the synergistic effect of rottlerin on interleukin1beta (IL-1beta)-induced COX-2 expression in MDA-MB-231 human breast cancer cell line.	rottlerin	95-104	interleukin 1 beta	Homo sapiens	126-134	
21971413-3	2011	Treatment with rottlerin enhanced IL-1beta-induced COX-2 expression at both the protein and mRNA levels.	rottlerin	15-24	interleukin 1 beta	Homo sapiens	34-42	
21804018-5	2011	Rottlerin, a PKCdelta-specific inhibitor, significantly reduced PMA-induced IL-1beta production as well as CD11b, TLR2 expression, and IRAK1-JNK activation.	rottlerin	0-9	interleukin 1 beta	Homo sapiens	76-84