PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17371872-9	2007	Pretreatment of MCF7/ADR cells with SP600125, a specific inhibitor of JNK, or with rottlerin, a specific inhibitor of protein kinase Cdelta (PKCdelta), significantly reduced the sangivamycin-induced apoptosis and almost completely abolished sangivamycin-induced phosphorylation of c-Jun and cleavage of lamin A and PARP.	rottlerin	83-92	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	281-286	
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	rottlerin	344-353	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	181-185	
18541274-5	2008	We also found that this inhibitory effect of zinc on AP-1 signaling was abolished by treatment with rottlerin, a selective inhibitor of calcium-independent protein kinase C (PKC).	rottlerin	100-109	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	53-57	
32500466-7	2021	A combination of Western blot assays and expression analyses by qRT-PCR ruled out that rottlerin may act indirectly through inhibition of c-Jun or Sp1 expression to decrease MACC-1 expression in human colon cancer cell lines SW620.	rottlerin	87-96	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-143	
32500466-6	2021	Electrophoretic mobility shift assays showed that rottlerin inhibits the binding of the transcriptional activators Sp1 and c-Jun with human MACC-1 promoter.	rottlerin	50-59	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-128	
32500466-8	2021	Rather, these results support that rottlerin restricts the binding of MACC-1 promoter directly by c-Jun and Sp1 in colon cancer cells.	rottlerin	35-44	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-103	
30685603-6	2019	Quercetin, rottlerin, SP600125 and U0126 attenuated TNF-alpha-stimulated c-Jun phosphorylation and AP-1-Luc activity.	rottlerin	11-20	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78	
25675437-9	2015	We observed that TNF-alpha induced c-Jun phosphorylation which was inhibited by Rottlerin or SP600125.	rottlerin	80-89	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-40