PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29550417-1 2018 This study revealed the modulatory role of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) cation channels in the Aldara-induced (5% imiquimod) murine psoriasis model using selective antagonists and genetically altered animals. Imiquimod 137-143 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 83-88 31111624-0 2019 Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod-induced, psoriasiform dermal inflammation in mice. Imiquimod 68-77 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 0-38 31111624-0 2019 Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod-induced, psoriasiform dermal inflammation in mice. Imiquimod 68-77 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 40-45 31111624-5 2019 Compared with WT mice, clinical scores, skin thickness change and TEWL scores were similar on day 3, but were significantly decreased on day 5 in IMQ-treated TRPA1 KO mice (vs WT mice), suggesting reduced inflammation and skin barrier defects. Imiquimod 146-149 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 158-163 29550417-0 2018 TRPA1 Acts in a Protective Manner in Imiquimod-Induced Psoriasiform Dermatitis in Mice. Imiquimod 37-46 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 0-5 29550417-1 2018 This study revealed the modulatory role of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) cation channels in the Aldara-induced (5% imiquimod) murine psoriasis model using selective antagonists and genetically altered animals. Imiquimod 137-143 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 43-81 29561265-4 2018 In the zebrafish, imiquimod-evoked somatosensory neuronal responses and behaviors were entirely dependent upon TRPA1, while in the mouse TRPA1 was required for the direct activation of somatosensory neurons and partially responsible for behaviors elicited by this pruritogen. Imiquimod 18-27 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 137-142