PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33278951-2 2021 In this study, we investigated the biological effect of beta-glucan from Schizophyllum commune, called Schizophyllan (SPG) on Interleukin-10 (IL-10) expression induced by a lipopolysaccharide (LPS) from Aggregatibacter actinomycetemcomitans in murine macrophages (J774.1). spirogermanium 118-121 interleukin 10 Mus musculus 142-147 33278951-4 2021 The regulative effect of SPG on IL-10 expression is dependent on prolongation of nuclear translocation activity of nuclear factor-kappa B (NF-kappaBalpha) pathway induced by LPS. spirogermanium 25-28 interleukin 10 Mus musculus 32-37 33278951-5 2021 We also found that LPS-induced phosphorylation of mitogen- and stress-activated protein kinase 1 (MSK1) and cAMP-responsive-element-binding protein (CREB), followed by up-regulation of IL-10, was stimulated by SPG priming via activation of the spleen tyrosine kinase (Syk). spirogermanium 210-213 interleukin 10 Mus musculus 185-190