PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30422809-0 2019 Antitumor effects of beta-elemene via targeting the phosphorylation of insulin receptor. beta-elemene 21-33 insulin receptor Homo sapiens 71-87 30422809-6 2019 To investigate the mechanisms, we focused on the effects of beta-elemene on IR signaling pathway. beta-elemene 60-72 insulin receptor Homo sapiens 76-78 30422809-8 2019 Further, the phosphorylation of IR was found to be suppressed notably by beta-elemene specifically in tumor cells but not normal hepatocytes. beta-elemene 73-85 insulin receptor Homo sapiens 32-34 30422809-9 2019 In addition, beta-elemene inhibited the growth of ESFT xenografts in vivo, and the phosphorylation of IR and S6 ribosomal protein was significantly repressed in the beta-elemene-treated xenografts. beta-elemene 165-177 insulin receptor Homo sapiens 102-104 30422809-10 2019 These data suggest that beta-elemene targets IR phosphorylation to inhibit the proliferation of tumor cells specifically and enhace the effects of IGF1R inhibitors. beta-elemene 24-36 insulin receptor Homo sapiens 45-47