PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33758606-6 2021 Compared with erlotinib alone, beta-elemene plus erlotinib significantly promoted the apoptosis of NCI-H1975 cells, accompanied by the down-regulated expression of P-mTOR, P-EGFR, CHOP proteins and up-regulated expression of P-AMPKalpha and Bax proteins. beta-elemene 31-43 epidermal growth factor receptor Homo sapiens 174-178 31343107-6 2019 Further analysis revealed that beta-elemene suppressed aerobic glycolysis by blocking PKM2 nuclear translocation and the expression of EGFR, GLUT1 and LDHA by influencing the expression of importin alpha5. beta-elemene 31-43 epidermal growth factor receptor Homo sapiens 135-139 32199253-0 2020 beta-Elemene inhibits the metastasis of multidrug-resistant gastric cancer cells through miR-1323/Cbl-b/EGFR pathway. beta-elemene 0-12 epidermal growth factor receptor Homo sapiens 104-108 32199253-12 2020 Further studies showed that beta-Elemene upregulated Cbl-b expression, resulting in inhibition of the EGFR-ERK/AKT pathways, which regulate MMP-2/9. beta-elemene 28-40 epidermal growth factor receptor Homo sapiens 102-106 32199253-15 2020 CONCLUSION: Our results suggested that beta-Elemene inhibits the metastasis of MDR gastric cancer cells by modulating the miR-1323/Cbl-b/EGFR signaling axis. beta-elemene 39-51 epidermal growth factor receptor Homo sapiens 137-141 27498706-0 2016 beta-Elemene enhances the efficacy of gefitinib on glioblastoma multiforme cells through the inhibition of the EGFR signaling pathway. beta-elemene 0-12 epidermal growth factor receptor Homo sapiens 111-115 27498706-6 2016 The combination medication of beta-elemene and gefitinib not only inhibited the survival and proliferation of glioblastoma multiforme cells via inhibition of EGFR signaling pathway but also induced more distinct apoptosis and autophagy in the glioblastoma multiforme cells than the gefitinib monotherapy. beta-elemene 30-42 epidermal growth factor receptor Homo sapiens 158-162 27498706-7 2016 These results showed that beta-elemene might be one potential adjuvant to enhance the effect of EGFR inhibitor and reduce the resistance of gefitinib in glioblastoma multiforme. beta-elemene 26-38 epidermal growth factor receptor Homo sapiens 96-100