PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24535052-0 2014 beta-Elemene inhibits the metastasis of B16F10 melanoma cells by downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9. beta-elemene 0-12 plasminogen activator, urokinase Mus musculus 101-104 25405459-0 2015 Inhibition of tumor growth by beta-elemene through downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9 in a murine intraocular melanoma model. beta-elemene 30-42 plasminogen activator, urokinase Mus musculus 87-90 25405459-6 2015 Tumor size was inhibited by beta-elemene in the treatment group, and the expressions of uPA, uPAR, MMP-2, and MMP-9 were all downregulated at both the mRNA and the protein level compared with the control group. beta-elemene 28-40 plasminogen activator, urokinase Mus musculus 88-91 25405459-7 2015 In a mouse model of intraocular melanoma, beta-elemene inhibits tumor growth by downregulating the expression of uPA, uPAR, MMP-2, and MMP-9. beta-elemene 42-54 plasminogen activator, urokinase Mus musculus 113-116 24535052-9 2014 The expression of uPA, uPAR, MMP-2, and MMP-9 was reduced by beta-elemene at both the mRNA and protein level. beta-elemene 61-73 plasminogen activator, urokinase Mus musculus 18-21 24535052-10 2014 beta-Elemene inhibits the metastasis of B16F10 melanoma cells through downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9. beta-elemene 0-12 plasminogen activator, urokinase Mus musculus 106-109 1589964-5 1992 The translated major open reading frame (ORF-1) from these clones indicates that this portion of the genome encodes a polyprotein with consensus sequences found in RNA-dependent RNA polymerase and ATP/GTP binding domains. Guanosine Triphosphate 201-204 ORF1 Homo sapiens 41-46 1313420-1 1992 rab3A is a low molecular weight (LMW) GTP-binding protein specifically expressed in brain and localized to synaptic vesicles. Guanosine Triphosphate 38-41 RAB3A, member RAS oncogene family Rattus norvegicus 0-5 1313420-6 1992 Four additional clones, rab12, rab13, rab14, and rab15, revealed unique sequences and are new members of the rab family of LMW GTP-binding proteins. Guanosine Triphosphate 127-130 RAB14, member RAS oncogene family Rattus norvegicus 38-43 1550577-2 1992 In the particulate fraction, the activity of phospholipase A2 was enhanced 270% by 100 microM guanosine 5"-[gamma-thio]triphosphate, a hydrolysis-resistant analog of GTP. Guanosine Triphosphate 166-169 phospholipase A2 group IB Homo sapiens 45-61 1371994-6 1992 The addition of TNF alpha together with an unhydrolyzable analog of GTP, GTP gamma S, to the beta-escin-permeabilized cells prelabeled with [3H]arachidonic acid led to a release of the 3H radioactivity. Guanosine Triphosphate 73-76 tumor necrosis factor Mus musculus 16-25 1544886-4 1992 Here we show that both TGF beta 1 and TGF beta 2 (5 ng/ml) result in a rapid (within 6 or 12 min, respectively) stimulation of GTP bound to p21ras in TGF beta-sensitive intestinal epithelial cells. Guanosine Triphosphate 127-130 transforming growth factor beta 1 Homo sapiens 23-33 1544886-4 1992 Here we show that both TGF beta 1 and TGF beta 2 (5 ng/ml) result in a rapid (within 6 or 12 min, respectively) stimulation of GTP bound to p21ras in TGF beta-sensitive intestinal epithelial cells. Guanosine Triphosphate 127-130 transforming growth factor beta 1 Homo sapiens 23-31 1544886-5 1992 Further, the CCL64 epithelial cell line, extremely sensitive to growth inhibition by TGF beta, displayed a concentration-dependent increase in GTP bound to p21ras by TGF beta 1 and a rapid activation of p21ras by TGF beta 2. Guanosine Triphosphate 143-146 transforming growth factor beta 1 Homo sapiens 85-93 1544886-5 1992 Further, the CCL64 epithelial cell line, extremely sensitive to growth inhibition by TGF beta, displayed a concentration-dependent increase in GTP bound to p21ras by TGF beta 1 and a rapid activation of p21ras by TGF beta 2. Guanosine Triphosphate 143-146 transforming growth factor beta 1 Homo sapiens 166-176 1537851-4 1992 Although NPY(17-36) inhibited 125I-NPY binding with high potency, it produced a biphasic effect on basal (GTP, 10 and 100 microM or guanosine 5"-gamma-O-(thio)triphosphate (GTP gamma S, 10 microM) adenylate cyclase activity. Guanosine Triphosphate 106-109 neuropeptide Y Rattus norvegicus 9-12 1537852-2 1992 Association constants were determined by Scatchard plot analysis (the constants are given in units of [10(7)/M] measured at 15 mM Mg2+): the ternary complex Phe-tRNA.elongation factor EF-Tu.GTP (12 +/- 3), Phe-tRNA (1 +/- 0.4), AcPhe-tRNA (0.7 +/- 0.3), and deacylated tRNA(Phe) (0.4 +/- 0.15) bind with decreasing affinity to the A site of poly(U)-programmed ribosomes. Guanosine Triphosphate 190-193 Tu translation elongation factor, mitochondrial Homo sapiens 184-189 1537852-2 1992 Association constants were determined by Scatchard plot analysis (the constants are given in units of [10(7)/M] measured at 15 mM Mg2+): the ternary complex Phe-tRNA.elongation factor EF-Tu.GTP (12 +/- 3), Phe-tRNA (1 +/- 0.4), AcPhe-tRNA (0.7 +/- 0.3), and deacylated tRNA(Phe) (0.4 +/- 0.15) bind with decreasing affinity to the A site of poly(U)-programmed ribosomes. Guanosine Triphosphate 190-193 mitochondrially encoded tRNA glycine Homo sapiens 269-278 1546956-3 1992 To examine whether IL-8 receptors are coupled to activation of guanine-nucleotide-binding proteins (G-proteins), we have investigated the influence of IL-8 on GTP hydrolysis by and guanosine 5"-[gamma-[35S]thio]triphosphate (GTP[35S]) binding to purified human neutrophil plasma membranes. Guanosine Triphosphate 159-162 C-X-C motif chemokine ligand 8 Homo sapiens 19-23 1546956-3 1992 To examine whether IL-8 receptors are coupled to activation of guanine-nucleotide-binding proteins (G-proteins), we have investigated the influence of IL-8 on GTP hydrolysis by and guanosine 5"-[gamma-[35S]thio]triphosphate (GTP[35S]) binding to purified human neutrophil plasma membranes. Guanosine Triphosphate 159-162 C-X-C motif chemokine ligand 8 Homo sapiens 151-155 1546956-7 1992 High-affinity binding of GTP[35S] to neutrophil plasma membranes was stimulated half-maximally and maximally (up to 5-fold) by IL-8 at about 10 nM and 100 nM respectively. Guanosine Triphosphate 25-28 C-X-C motif chemokine ligand 8 Homo sapiens 127-131 1546956-8 1992 GTP[35S] binding to the membranes was also stimulated by two IL-8-related cytokines, neutrophil-activating peptide 2 (NAP-2) and melanoma growth-stimulatory activity (gro/MGSA). Guanosine Triphosphate 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 61-65 1545405-7 1992 Dithiothreitol and the nonhydrolyzable GTP analog, 5"-guanylyl-imidodiphosphate, inhibited AII binding to all three membrane preparations. Guanosine Triphosphate 39-42 angiotensinogen Rattus norvegicus 91-94 1543755-1 1992 Recently, we reported that in mouse mastocytoma P-815 cells the cytosol contains some factor(s) which promotes the release of GTP-activated Gi2 alpha from the membrane, and that thrombin induces the translocation of Gi2 alpha from the membrane to the cytosol (Takahashi, S., Negishi, M. and Ichikawa, A. Guanosine Triphosphate 126-129 coagulation factor II Mus musculus 178-186 1543755-8 1992 When cells were treated with thrombin, the ability of the cytosol to release Gi2 alpha from the membrane in the presence of GTP gamma S markedly increased. Guanosine Triphosphate 124-127 coagulation factor II Mus musculus 29-37 1313594-6 1992 Furthermore, in the presence of GTP, calcitonin stimulated adenylate cyclase activity in KATO III cell membranes, and this increase was reduced in the absence of GTP. Guanosine Triphosphate 32-35 calcitonin related polypeptide alpha Homo sapiens 37-47 1313594-9 1992 Furthermore, the specific binding of 125I-labeled human calcitonin to KATO III cell membranes was significantly reduced by addition of GTP but not ATP. Guanosine Triphosphate 135-138 calcitonin related polypeptide alpha Homo sapiens 56-66 1313594-10 1992 These results suggest that calcitonin inhibits the growth of human gastric carcinoma cell line KATO III by stimulating cyclic AMP production via a GTP-dependent process coupled to specific calcitonin receptors. Guanosine Triphosphate 147-150 calcitonin related polypeptide alpha Homo sapiens 27-37 1313594-10 1992 These results suggest that calcitonin inhibits the growth of human gastric carcinoma cell line KATO III by stimulating cyclic AMP production via a GTP-dependent process coupled to specific calcitonin receptors. Guanosine Triphosphate 147-150 calcitonin related polypeptide alpha Homo sapiens 189-199 1310685-8 1992 Since treatment of membranes with guanosine 5"-O-(3-thiotriphosphate) resulted in the separation of the VIP-cross-linked receptor from Gs such that no cross-linking could occur, we conclude that the binding of GTP analogs induces a conformational change in Gs in the membrane milieu. Guanosine Triphosphate 210-213 vasoactive intestinal peptide Rattus norvegicus 104-107 1551445-1 1992 ADP-ribosylation of recombinant rhoA and rhoB proteins by Clostridium botulinum C3 exoenzyme increased steady-state GTP hydrolysis by 50 to 80%. Guanosine Triphosphate 116-119 ras homolog family member A Homo sapiens 32-36 1551445-3 1992 In contrast, GTP hydrolysis by Ile-41 rhoA or Ha-ras, which are no substrates for the transferase, were not affected by C3. Guanosine Triphosphate 13-16 ras homolog family member A Homo sapiens 38-42 1551445-4 1992 ADP-ribosylation facilitated the [3H]GDP release and subsequently, the binding of [3H]GTP to rhoA. Guanosine Triphosphate 86-89 ras homolog family member A Homo sapiens 93-97 1733950-0 1992 Inhibition of interleukin 3 and granulocyte-macrophage colony-stimulating factor stimulated increase of active ras.GTP by herbimycin A, a specific inhibitor of tyrosine kinases. Guanosine Triphosphate 115-118 interleukin 3 Mus musculus 14-80 1733950-2 1992 Growth signals from IL-3 and GM-CSF cause accumulation of active Ras.GTP complexes in PT18 mouse mast cell line (Satoh, T., Nakafuku, M., Miyajima, A., and Kaziro, Y. Guanosine Triphosphate 69-72 interleukin 3 Mus musculus 20-24 1733950-10 1992 The increase of Ras.GTP induced by IL-3 and GM-CSF diminished in cells treated with 0.5 approximately 1 micrograms/ml of herbimycin A for 24 h prior to the addition of the growth factors. Guanosine Triphosphate 20-23 interleukin 3 Mus musculus 35-39 1616497-2 1992 T beta gamma-2 enhances GTP binding to the alpha-subunit of transducin (T alpha) in the presence of a photobleaching intermediate of rhodopsin, while T beta gamma-1 is an inactive component with little enhancement ability (Fukada, Y., Ohguro, H., Saito, T., Yoshizawa, T., and Akino, T. (1989) J. Biol. Guanosine Triphosphate 24-27 tryptophanyl-tRNA synthetase 1 Homo sapiens 7-14 1616497-2 1992 T beta gamma-2 enhances GTP binding to the alpha-subunit of transducin (T alpha) in the presence of a photobleaching intermediate of rhodopsin, while T beta gamma-1 is an inactive component with little enhancement ability (Fukada, Y., Ohguro, H., Saito, T., Yoshizawa, T., and Akino, T. (1989) J. Biol. Guanosine Triphosphate 24-27 rhodopsin Homo sapiens 133-142 1312995-6 1992 The present study indicates a modulation of the FMLP-induced leukotriene formation by diverse cytokines via interaction with the GTP-binding proteins. Guanosine Triphosphate 129-132 formyl peptide receptor 1 Homo sapiens 48-52 1495270-0 1992 The stimulatory GDP/GTP exchange protein for ras p21-related small GTP-binding proteins. Guanosine Triphosphate 20-23 cyclin dependent kinase inhibitor 1A Bos taurus 49-52 1495270-0 1992 The stimulatory GDP/GTP exchange protein for ras p21-related small GTP-binding proteins. Guanosine Triphosphate 67-70 cyclin dependent kinase inhibitor 1A Bos taurus 49-52 1495270-4 1992 smg p21 GDS stimulates the dissociation of [3H]GDP from and also stimulates the binding of [35S]guanosine 5"-(3-O-thio)triphosphate (GTP gamma S) to smg p21s. Guanosine Triphosphate 133-136 cyclin dependent kinase inhibitor 1A Bos taurus 4-7 1495270-7 1992 These results indicate that bovine brain contains regulatory proteins for smg p21s that stimulate the GDP/GTP exchange reaction of smg p21s in addition to smg p21 GAP. Guanosine Triphosphate 106-109 cyclin dependent kinase inhibitor 1A Bos taurus 78-81 1495270-7 1992 These results indicate that bovine brain contains regulatory proteins for smg p21s that stimulate the GDP/GTP exchange reaction of smg p21s in addition to smg p21 GAP. Guanosine Triphosphate 106-109 cyclin dependent kinase inhibitor 1A Bos taurus 135-138 1495270-8 1992 It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP. Guanosine Triphosphate 85-88 cyclin dependent kinase inhibitor 1A Bos taurus 73-76 1495270-8 1992 It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP. Guanosine Triphosphate 85-88 cyclin dependent kinase inhibitor 1A Bos taurus 127-130 1495270-8 1992 It is likely that the conversion from the GDP-bound inactive form of smg p21s to the GTP-bound active form is regulated by smg p21 GDS and that its reverse reaction is regulated by smg p21 GAP. Guanosine Triphosphate 85-88 cyclin dependent kinase inhibitor 1A Bos taurus 127-130 1549351-2 1992 smg GDS stimulates the GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins), including at least c-Ki-ras p21, smg p21A, smg p21B, rhoA p21 and rhoB p21, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. Guanosine Triphosphate 27-30 cyclin dependent kinase inhibitor 1A Bos taurus 132-135 1549351-2 1992 smg GDS stimulates the GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins), including at least c-Ki-ras p21, smg p21A, smg p21B, rhoA p21 and rhoB p21, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. Guanosine Triphosphate 27-30 cyclin dependent kinase inhibitor 1A Bos taurus 141-144 1549351-2 1992 smg GDS stimulates the GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins), including at least c-Ki-ras p21, smg p21A, smg p21B, rhoA p21 and rhoB p21, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. Guanosine Triphosphate 27-30 cyclin dependent kinase inhibitor 1A Bos taurus 141-144 1549351-2 1992 smg GDS stimulates the GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins), including at least c-Ki-ras p21, smg p21A, smg p21B, rhoA p21 and rhoB p21, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. Guanosine Triphosphate 69-72 cyclin dependent kinase inhibitor 1A Bos taurus 132-135 1549351-2 1992 smg GDS stimulates the GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins), including at least c-Ki-ras p21, smg p21A, smg p21B, rhoA p21 and rhoB p21, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. Guanosine Triphosphate 69-72 cyclin dependent kinase inhibitor 1A Bos taurus 141-144 1549351-2 1992 smg GDS stimulates the GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins), including at least c-Ki-ras p21, smg p21A, smg p21B, rhoA p21 and rhoB p21, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. Guanosine Triphosphate 69-72 cyclin dependent kinase inhibitor 1A Bos taurus 141-144 1549351-2 1992 smg GDS stimulates the GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins), including at least c-Ki-ras p21, smg p21A, smg p21B, rhoA p21 and rhoB p21, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. Guanosine Triphosphate 69-72 cyclin dependent kinase inhibitor 1A Bos taurus 132-135 1549351-2 1992 smg GDS stimulates the GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins), including at least c-Ki-ras p21, smg p21A, smg p21B, rhoA p21 and rhoB p21, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. Guanosine Triphosphate 69-72 cyclin dependent kinase inhibitor 1A Bos taurus 141-144 1549351-2 1992 smg GDS stimulates the GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins), including at least c-Ki-ras p21, smg p21A, smg p21B, rhoA p21 and rhoB p21, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. Guanosine Triphosphate 69-72 cyclin dependent kinase inhibitor 1A Bos taurus 141-144 1370436-10 1992 These results were also correlated with an in vitro activation of adenylyl cyclase activity by retinoic acid and inhibition of this activity by IFN-gamma, in a dose-dependent and a GTP-dependent manner. Guanosine Triphosphate 181-184 interferon gamma Homo sapiens 144-153 1370468-6 1992 Cyclic GMP alone with increase the conductance with a Km of 3.7 +/- 0.6 x 10(-7) M. In the absence of calcium, the unitary conductance with insulin + GTP or cGMP at 150 mM NaCl is 153 picosiemens. Guanosine Triphosphate 150-153 insulin Homo sapiens 140-147 1730631-12 1992 These results suggested that the agonist-fMLP receptor complex was effectively coupled with the ADP-ribosylated Gi-2, resulting in the GTP-bound form, and that the hydrolysis of GTP on the modified alpha-subunit was selectively attenuated. Guanosine Triphosphate 135-138 formyl peptide receptor 1 Homo sapiens 41-54 1730631-12 1992 These results suggested that the agonist-fMLP receptor complex was effectively coupled with the ADP-ribosylated Gi-2, resulting in the GTP-bound form, and that the hydrolysis of GTP on the modified alpha-subunit was selectively attenuated. Guanosine Triphosphate 178-181 formyl peptide receptor 1 Homo sapiens 41-54