PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30209296-0 2018 Inactivation of Stat3 and crosstalk of miRNA155-5p and FOXO3a contribute to the induction of IGFBP1 expression by beta-elemene in human lung cancer. beta-elemene 114-126 microRNA 155 Homo sapiens 39-47 30209296-4 2018 Mechanistically, we found that beta-elemene decreased the phosphorylation of signal transducer and activator of transcription 3 (Stat3) and miRNA155-5p mRNA but induced the protein expression of human forkhead box class O (FOXO)3a; the latter two were abrogated in cells with overexpressed Stat3. beta-elemene 31-43 microRNA 155 Homo sapiens 140-148 30209296-6 2018 Moreover, beta-elemene increased the mRNA and protein expression levels as well as promoter activity of insulin-like growth factor-binding protein 1 (IGFBP1); this finding was not observed in cells with a silenced FOXO3a gene and miRNA155-5p mimics. beta-elemene 10-22 microRNA 155 Homo sapiens 230-238 30209296-9 2018 In summary, our results indicate that beta-elemene increases IGFBP1 gene expression via inactivation of Stat3 followed by a reciprocal interaction between miRNA155-5p and FOXO3a. beta-elemene 38-50 microRNA 155 Homo sapiens 155-163