PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34257541-0	2021	beta-Elemene Triggers ROS-dependent Apoptosis in Glioblastoma Cells Through Suppressing STAT3 Signaling Pathway.	beta-elemene	0-12	signal transducer and activator of transcription 3	Homo sapiens	88-93	
34257541-8	2021	Overall, our findings implied that generation of ROS and suppression of STAT3 signaling pathway is critical for the apoptotic activity of beta-elemene in glioblastoma cells.	beta-elemene	138-150	signal transducer and activator of transcription 3	Homo sapiens	72-77	
34257541-6	2021	Western blot assay showed that beta-elemene suppressed phosphorylation of STAT3, and subsequently down-regulated the activation of p-JAK2 and p-Src.	beta-elemene	31-43	signal transducer and activator of transcription 3	Homo sapiens	74-79	
32401925-9	2020	In conclusion, the data suggested that beta-elemene+paclitaxel can inhibit ovarian cancer growth via down-regulation of the STAT3-NF-kappaB signaling pathway, which may be a potential therapeutic strategy for ovarian cancer therapy.	beta-elemene	39-51	signal transducer and activator of transcription 3	Homo sapiens	124-129	
35628363-3	2022	Previous studies have shown that signaling factors such as JAK2/STAT3, Smad3, and Myd88 play a regulatory role in renal fibrosis, and beta-elemene is a plant-derived sesquiterpenoid organic compound that has been shown to have anti-inflammatory, anti-cancer, and immunomodulatory effects.	beta-elemene	134-146	signal transducer and activator of transcription 3	Homo sapiens	64-69	
28355175-0	2017	Synergistic Cytotoxicity of beta-Elemene and Cisplatin in Gingival Squamous Cell Carcinoma by Inhibition of STAT3 Signaling Pathway.	beta-elemene	28-40	signal transducer and activator of transcription 3	Homo sapiens	108-113	
28355175-3	2017	beta-elemene, isolated from the Chinese herb Rhizoma zedoariahas, is highly effective against malignancies and has low toxicity, but the development of beta-elemene sensitizing chemotherapy in targeting the STAT3 signaling pathway remains unexplored in gingival squamous cell carcinoma.	beta-elemene	0-12	signal transducer and activator of transcription 3	Homo sapiens	207-212	
28355175-3	2017	beta-elemene, isolated from the Chinese herb Rhizoma zedoariahas, is highly effective against malignancies and has low toxicity, but the development of beta-elemene sensitizing chemotherapy in targeting the STAT3 signaling pathway remains unexplored in gingival squamous cell carcinoma.	beta-elemene	152-164	signal transducer and activator of transcription 3	Homo sapiens	207-212	
28355175-8	2017	Cisplatin combined with beta-elemene decreased the expressions of p-STAT3, p-JAK2, and Bcl-2, and increased the expressions of Bax and caspase-3 significantly compared to cisplatin only treatment, as well as in the xenograft model.	beta-elemene	24-36	signal transducer and activator of transcription 3	Homo sapiens	68-73	
28355175-9	2017	CONCLUSIONS The results indicated that beta-elemene promoted the anti-proliferative and apoptotic effect of cisplatin by inhibiting STAT3 and blocking the JAK2-STAT3 signaling pathway in GSCC in vitro and in vivo.	beta-elemene	39-51	signal transducer and activator of transcription 3	Homo sapiens	132-137	
28355175-9	2017	CONCLUSIONS The results indicated that beta-elemene promoted the anti-proliferative and apoptotic effect of cisplatin by inhibiting STAT3 and blocking the JAK2-STAT3 signaling pathway in GSCC in vitro and in vivo.	beta-elemene	39-51	signal transducer and activator of transcription 3	Homo sapiens	160-165	
30209296-0	2018	Inactivation of Stat3 and crosstalk of miRNA155-5p and FOXO3a contribute to the induction of IGFBP1 expression by beta-elemene in human lung cancer.	beta-elemene	114-126	signal transducer and activator of transcription 3	Homo sapiens	16-21	
30209296-4	2018	Mechanistically, we found that beta-elemene decreased the phosphorylation of signal transducer and activator of transcription 3 (Stat3) and miRNA155-5p mRNA but induced the protein expression of human forkhead box class O (FOXO)3a; the latter two were abrogated in cells with overexpressed Stat3.	beta-elemene	31-43	signal transducer and activator of transcription 3	Homo sapiens	77-127	
30209296-4	2018	Mechanistically, we found that beta-elemene decreased the phosphorylation of signal transducer and activator of transcription 3 (Stat3) and miRNA155-5p mRNA but induced the protein expression of human forkhead box class O (FOXO)3a; the latter two were abrogated in cells with overexpressed Stat3.	beta-elemene	31-43	signal transducer and activator of transcription 3	Homo sapiens	129-134	
30209296-4	2018	Mechanistically, we found that beta-elemene decreased the phosphorylation of signal transducer and activator of transcription 3 (Stat3) and miRNA155-5p mRNA but induced the protein expression of human forkhead box class O (FOXO)3a; the latter two were abrogated in cells with overexpressed Stat3.	beta-elemene	31-43	signal transducer and activator of transcription 3	Homo sapiens	290-295	
30209296-9	2018	In summary, our results indicate that beta-elemene increases IGFBP1 gene expression via inactivation of Stat3 followed by a reciprocal interaction between miRNA155-5p and FOXO3a.	beta-elemene	38-50	signal transducer and activator of transcription 3	Homo sapiens	104-109