PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20663036-12 2010 Moreover, beta-elemene exposure resulted in a decreased Bcl-2 protein level, increased cytochrome c release, and activated PARP and caspase-3, -7, -9, and -10 in prostate cancer cells. beta-elemene 10-22 caspase 3 Homo sapiens 132-158 25556484-7 2014 Real-time quantitative PCR and Western-blotting assay were performed to investigated the influence of beta-elemene on expression levels of Fas/FasL, caspase-3, Bcl-2 and Bax. beta-elemene 102-114 caspase 3 Homo sapiens 149-158 25556484-12 2014 Activation of caspase-3,-8 and -9 was increased and the pro-apoptotic factors Fas/FasL and Bax were upregulated, while the anti-apoptotic Bcl-2 was downregulated after treatment with beta-elemene at both mRNA and protein levels. beta-elemene 183-195 caspase 3 Homo sapiens 14-33 22843880-9 2012 Moreover, beta-elemene triggered apoptosis and irreversible cell death in both sensitive and resistant ovarian cancer cells via the activation of caspase-3, -8 and 9; the loss of mitochondrial membrane potential (deltaPsim); the release of cytochrome c into the cytosol; and changes in the expression of BCL-2 family proteins. beta-elemene 10-22 caspase 3 Homo sapiens 146-165 22545969-7 2010 beta-Elemene augmented the cisplatin-induced activation of caspase-3/7/10 and caspase-9, cleavage of caspase-3 and -9, suppression of Bcl-2 and Bcl-X(L) expression, and release of cytochrome c from mitochondria in these cells. beta-elemene 0-12 caspase 3 Homo sapiens 59-73 22545969-7 2010 beta-Elemene augmented the cisplatin-induced activation of caspase-3/7/10 and caspase-9, cleavage of caspase-3 and -9, suppression of Bcl-2 and Bcl-X(L) expression, and release of cytochrome c from mitochondria in these cells. beta-elemene 0-12 caspase 3 Homo sapiens 101-117 23564782-6 2013 beta-Elemene-enhanced cisplatin cytotoxicity was associated with increased apoptotic cell death, as determined by DNA fragmentation, and increased activities of caspase-3, -7, -8, -9, and -10 in bladder cancer cell lines. beta-elemene 0-12 caspase 3 Homo sapiens 161-191 19513519-6 2009 Finally, beta-elemene augmented the cisplatin-induced increases in caspase-3, -7, -9 and -10 activities and cleaved caspase-3, -9 and poly(ADP-ribose) polymerase levels in NSCLC cells. beta-elemene 9-21 caspase 3 Homo sapiens 67-92 20416170-4 2010 The effects of beta-elemene on the expression of BCL-2, caspase-3, DR-4 and NF-kappaB P65 proteins were analyzed by Western blot. beta-elemene 15-27 caspase 3 Homo sapiens 56-65 20416170-7 2010 The expression of caspase-3 and DR-4 proteins in RPMI-8226 cells treated with beta-elemene increased in a time-dependent manner, while expressions of BCL-2 and NF-kappaB P65 proteins decreased. beta-elemene 78-90 caspase 3 Homo sapiens 18-27 34257541-5 2021 Incubation of these cells with beta-elemene led to the activation of caspase-3 and generation of reactive oxygen species (ROS). beta-elemene 31-43 caspase 3 Homo sapiens 69-78 26721344-6 2016 beta-Elemene-treated FLS showed a significant decline in mitochondrial membrane potential, an accumulation of cytochrome c in the cytosol, and increased activities of caspase-9 and caspase-3. beta-elemene 0-12 caspase 3 Homo sapiens 181-190 28355175-8 2017 Cisplatin combined with beta-elemene decreased the expressions of p-STAT3, p-JAK2, and Bcl-2, and increased the expressions of Bax and caspase-3 significantly compared to cisplatin only treatment, as well as in the xenograft model. beta-elemene 24-36 caspase 3 Homo sapiens 135-144