PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35628363-0 2022 beta-Elemene Attenuates Renal Fibrosis in the Unilateral Ureteral Obstruction Model by Inhibition of STAT3 and Smad3 Signaling via Suppressing MyD88 Expression. beta-elemene 0-12 signal transducer and activator of transcription 3 Rattus norvegicus 101-106 35628363-6 2022 Further experiments showed that beta-elemene reduced the expression levels of the above-mentioned fibrosis-related proteins by blocking the phosphorylation of JAK2/STAT3, Smad3, and the expression or up-regulation of MyD88. beta-elemene 32-44 signal transducer and activator of transcription 3 Rattus norvegicus 164-169 35628363-7 2022 Notably, knockdown of MyD88 attenuated the phosphorylation levels of STAT3 and Smad3 in TGF-beta stimulated NRK49F cell, which may be a novel molecular mechanism by which beta-elemene affects renal interstitial fibrosis. beta-elemene 171-183 signal transducer and activator of transcription 3 Rattus norvegicus 69-74