PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27174018-8 2017 Inhibition study using rosuvastatin as the substrate in OATP1B1- and OATP1B3-transfected cells indicated that curcumin was an OATP1B1 and 1B3 inhibitor, with IC50 at 5.19 +- 0.05 and 3.68 +- 0.05 muM, respectively; the data for COG were 1.04 +- 0.01 and 1.08 +- 0.02 muM, respectively. Rosuvastatin Calcium 23-35 solute carrier organic anion transporter family member 1B3 Homo sapiens 69-76 33123800-2 2020 This study was to investigate the effect of scutellarin on the uptake of rosuvastatin in HEK293T cells expressing human organic anion transporting polypeptide 1B3 (hOATP1B3) and rat OATP1B2 (rOATP1B2), respectively, and the effect of scutellarin on the pharmacokinetics of rosuvastatin in rats. Rosuvastatin Calcium 73-85 solute carrier organic anion transporter family member 1B3 Homo sapiens 164-172 33123800-5 2020 RESULTS: Scutellarin inhibited hOATP1B3- and rOATP1B2-mediated rosuvastatin uptake (IC50: 45.54 +- 6.67 muM and 27.58 +- 3.97 muM) in vitro in a concentration-dependent manner. Rosuvastatin Calcium 63-75 solute carrier organic anion transporter family member 1B3 Homo sapiens 31-39 33123800-9 2020 CONCLUSION: Scutellarin may inhibit the hOATP1B3- and rOATP1B2-mediated transport of rosuvastatin in vitro, and exerts a moderate inhibitory effect on the pharmacokinetics of rosuvastatin in rats. Rosuvastatin Calcium 85-97 solute carrier organic anion transporter family member 1B3 Homo sapiens 40-48 29944058-6 2019 The uptake of rosuvastatin in OATP1B3-HEK293T cells was scarcely influenced by MA, MB and OPD, but was considerably increased by OPD" with an EC50 of 14.95 +- 1.62 muM. Rosuvastatin Calcium 14-26 solute carrier organic anion transporter family member 1B3 Homo sapiens 30-37 30652318-4 2019 Consequently, pitavastatin, pravastatin and rosuvastatin were suggested to be substrates of recombinant monkey OATP1B1 and OATP1B3, and telmisartan was suggested to be a substrate of recombinant monkey OATP1B3, in a manner similar to human OATPs. Rosuvastatin Calcium 44-56 solute carrier organic anion transporter family member 1B3 Homo sapiens 123-130 30652318-4 2019 Consequently, pitavastatin, pravastatin and rosuvastatin were suggested to be substrates of recombinant monkey OATP1B1 and OATP1B3, and telmisartan was suggested to be a substrate of recombinant monkey OATP1B3, in a manner similar to human OATPs. Rosuvastatin Calcium 44-56 solute carrier organic anion transporter family member 1B3 Homo sapiens 202-209 29719454-2 2018 Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3, NTCP, and BCRP transporters. Rosuvastatin Calcium 0-12 solute carrier organic anion transporter family member 1B3 Homo sapiens 52-59 27737931-1 2017 Rosuvastatin is a widely prescribed antihyperlipidemic which undergoes limited metabolism, but is an in vitro substrate of multiple transporters [organic anion transporting polypeptide 1B1 (OATP1B1), OATP1B3, OATP1A2, OATP2B1, sodium-taurocholate cotransporting polypeptide, breast cancer resistance protein (BCRP), multidrug resistance protein 2 (MRP2), MRP4, organic anion transporter 3]. Rosuvastatin Calcium 0-12 solute carrier organic anion transporter family member 1B3 Homo sapiens 200-207 21717139-6 2011 Therefore, the present results suggested that the potential drug interaction between danshensu or ursolic acid and rosuvastatin may be mediated by one or more transporters (OATP1B1, OATP 1B3, OATP 1A2, BCRP and NTCP) and/or CYPs. Rosuvastatin Calcium 115-127 solute carrier organic anion transporter family member 1B3 Homo sapiens 182-190 25261337-5 2014 The uptake activity was measured in HEK293 cell-lines stably overexpressing OATP1B1(*)1a, OATP1B3 or OATP2B1, the major transporters involved in human hepatic uptake of rosuvastatin, or expressing OATP1B1(*)15, associated with reduced hepatic uptake of rosuvastatin. Rosuvastatin Calcium 169-181 solute carrier organic anion transporter family member 1B3 Homo sapiens 90-97 21717139-5 2011 Rosuvastatin is a substrate of drug transporters such as human OATP1B1, OATP 1B3, OATP 1A2, BCRP and NTCP. Rosuvastatin Calcium 0-12 solute carrier organic anion transporter family member 1B3 Homo sapiens 72-80 34664206-1 2021 PURPOSE: To build a physiologically based pharmacokinetic (PBPK) model of the clinical OATP1B1/OATP1B3/BCRP victim drug rosuvastatin for the investigation and prediction of its transporter-mediated drug-drug interactions (DDIs). Rosuvastatin Calcium 120-132 solute carrier organic anion transporter family member 1B3 Homo sapiens 95-102 34664206-5 2021 The processes implemented to describe the rosuvastatin pharmacokinetics and DDIs are active uptake by OATP2B1, OATP1B1/OATP1B3 and OAT3, active efflux by BCRP and Pgp, metabolism by CYP2C9 and passive glomerular filtration. Rosuvastatin Calcium 42-54 solute carrier organic anion transporter family member 1B3 Homo sapiens 119-126 18617601-4 2008 Uptake studies revealed that human organic anion transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1 accept rosuvastatin as a substrate. Rosuvastatin Calcium 114-126 solute carrier organic anion transporter family member 1B3 Homo sapiens 86-93 18617601-5 2008 Among the OATP family transporters, OATP1B1 contributes predominantly to the hepatic uptake of rosuvastatin, as estimated with the previously published relative activity factor method, and OATP1B3 is also partly involved. Rosuvastatin Calcium 95-107 solute carrier organic anion transporter family member 1B3 Homo sapiens 189-196 33553369-0 2021 Late response to rosuvastatin and statin-related myalgia due to SLCO1B1, SLCO1B3, ABCB11, and CYP3A5 variants in a patient with Familial Hypercholesterolemia: a case report. Rosuvastatin Calcium 17-29 solute carrier organic anion transporter family member 1B3 Homo sapiens 73-80