PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28711499-5 2017 Our previous study found that Raloxifene inhibited IL-6/GP130 interaction, resulting in blockade of STAT3 phosphorylation. Raloxifene Hydrochloride 30-40 interleukin 6 cytokine family signal transducer Homo sapiens 56-61 29714141-13 2019 Consistently, other IL-6/GP130 inhibitors SC144 and evista showed similar inhibition of IL-6 stimulated cell viability, cell proliferation and glycolysis. Raloxifene Hydrochloride 52-58 interleukin 6 cytokine family signal transducer Homo sapiens 25-30 32940862-0 2021 Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERbeta and IL-6/gp130/STAT3 signaling. Raloxifene Hydrochloride 0-10 interleukin 6 cytokine family signal transducer Homo sapiens 89-94 28430601-4 2017 We reported the discovery of EVISTA (Raloxifene HCl) as novel inhibitor of IL-6/GP130 protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning. Raloxifene Hydrochloride 37-51 interleukin 6 cytokine family signal transducer Homo sapiens 80-85 28430601-0 2017 Growth-suppressive activity of raloxifene on liver cancer cells by targeting IL-6/GP130 signaling. Raloxifene Hydrochloride 31-41 interleukin 6 cytokine family signal transducer Homo sapiens 82-87 28430601-4 2017 We reported the discovery of EVISTA (Raloxifene HCl) as novel inhibitor of IL-6/GP130 protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning. Raloxifene Hydrochloride 29-35 interleukin 6 cytokine family signal transducer Homo sapiens 80-85 28430601-12 2017 CONCLUSIONS: Our results suggest that Raloxifene is a potent IL-6/GP130 inhibitor and may be a chemoprevention agent for liver cancer by targeting persistent STAT3 signaling. Raloxifene Hydrochloride 38-48 interleukin 6 cytokine family signal transducer Homo sapiens 66-71 24456369-0 2014 Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface. Raloxifene Hydrochloride 145-155 interleukin 6 cytokine family signal transducer Homo sapiens 201-206 24456369-2 2014 We report here the discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning approaches. Raloxifene Hydrochloride 32-42 interleukin 6 cytokine family signal transducer Homo sapiens 88-93 24456369-4 2014 Similarity searches of virtual hits on drug databases identified raloxifene and bazedoxifene as potential inhibitors of IL-6/GP130 interaction. Raloxifene Hydrochloride 65-75 interleukin 6 cytokine family signal transducer Homo sapiens 125-130