PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29032766-8	2017	Menadione and raloxifene weakly inhibited Bcrp1, but the inhibition of raloxifene on MDR1 was as potent as on the xanthine oxidase pterin oxidation.	Raloxifene Hydrochloride	71-81	ATP binding cassette subfamily B member 1	Homo sapiens	85-89	
16959878-0	2006	The role of P-glycoprotein in the bioactivation of raloxifene.	Raloxifene Hydrochloride	51-61	ATP binding cassette subfamily B member 1	Homo sapiens	12-26	
22683417-2	2012	The aim of our study was to identify transporters involved in the efflux of raloxifene and its glucuronide metabolites by various in vitro models and by an in vivo study to explore the possible involvement of P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP)1, MRP2, MRP3, and breast cancer resistance protein in the observed high interindividual variability.	Raloxifene Hydrochloride	76-86	ATP binding cassette subfamily B member 1	Homo sapiens	209-223	
22683417-2	2012	The aim of our study was to identify transporters involved in the efflux of raloxifene and its glucuronide metabolites by various in vitro models and by an in vivo study to explore the possible involvement of P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP)1, MRP2, MRP3, and breast cancer resistance protein in the observed high interindividual variability.	Raloxifene Hydrochloride	76-86	ATP binding cassette subfamily B member 1	Homo sapiens	225-228	
22683417-4	2012	Caco-2 cell monolayer experiments indicated an interaction of raloxifene with Pgp.	Raloxifene Hydrochloride	62-72	ATP binding cassette subfamily B member 1	Homo sapiens	78-81	
22683417-5	2012	The ATPase assay confirmed the raloxifene interaction with Pgp and indicated interactions of all raloxifene species with MRP1, MRP2, MRP3, and breast cancer resistance protein, except for M1, which did not show any interactions with MRP2.	Raloxifene Hydrochloride	31-41	ATP binding cassette subfamily B member 1	Homo sapiens	59-62	
22683417-9	2012	The results of our study support the involvement of efflux transporters in disposition of raloxifene and its metabolites and may partially explain the observed raloxifene variability by the influence of the ABCB1 c.3435C>T polymorphism.	Raloxifene Hydrochloride	90-100	ATP binding cassette subfamily B member 1	Homo sapiens	207-212	
22683417-9	2012	The results of our study support the involvement of efflux transporters in disposition of raloxifene and its metabolites and may partially explain the observed raloxifene variability by the influence of the ABCB1 c.3435C>T polymorphism.	Raloxifene Hydrochloride	160-170	ATP binding cassette subfamily B member 1	Homo sapiens	207-212	
16959878-3	2006	The aim of this work was to examine the role of P-glycoprotein (Pgp) in the bioactivation of a Pgp substrate, raloxifene, and a non-Pgp substrate, naphthalene.	Raloxifene Hydrochloride	110-120	ATP binding cassette subfamily B member 1	Homo sapiens	48-62	
16959878-3	2006	The aim of this work was to examine the role of P-glycoprotein (Pgp) in the bioactivation of a Pgp substrate, raloxifene, and a non-Pgp substrate, naphthalene.	Raloxifene Hydrochloride	110-120	ATP binding cassette subfamily B member 1	Homo sapiens	64-67	
16959878-7	2006	In addition, the measure of raloxifene-glutathione adducts in the cryopreserved hepatocytes showed that the formation of the adducts increased in the presence of verapamil, which supports the idea that blocking Pgp in the liver increases metabolism and, therefore, the bioactivation of raloxifene.	Raloxifene Hydrochloride	28-38	ATP binding cassette subfamily B member 1	Homo sapiens	211-214	
16959878-7	2006	In addition, the measure of raloxifene-glutathione adducts in the cryopreserved hepatocytes showed that the formation of the adducts increased in the presence of verapamil, which supports the idea that blocking Pgp in the liver increases metabolism and, therefore, the bioactivation of raloxifene.	Raloxifene Hydrochloride	286-296	ATP binding cassette subfamily B member 1	Homo sapiens	211-214	
17096884-6	2006	Cyclosporine A and raloxifene (alone or combination) elevated the intracellular DNR concentration in K562/A02, down regulated P-gp and mdr-1 mRNA expressions.	Raloxifene Hydrochloride	19-29	ATP binding cassette subfamily B member 1	Homo sapiens	126-130	
17096884-6	2006	Cyclosporine A and raloxifene (alone or combination) elevated the intracellular DNR concentration in K562/A02, down regulated P-gp and mdr-1 mRNA expressions.	Raloxifene Hydrochloride	19-29	ATP binding cassette subfamily B member 1	Homo sapiens	135-140