PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31495284-0 2019 Salidroside inhibits MAPK, NF-kappaB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation. rhodioloside 0-11 sirtuin 1 Homo sapiens 102-107 31495284-7 2019 Salidroside, the main ingredient of Rhodiola, is known to exert antioxidant roles, which has been attributed to SIRT1 activation. rhodioloside 0-11 sirtuin 1 Homo sapiens 112-117 31495284-8 2019 Conclusion: Salidroside might inhibit oxidative stress singling pathways via SIRT1 activation, and could be as an ideal candidate for management of psoriasis. rhodioloside 12-23 sirtuin 1 Homo sapiens 77-82 31612074-0 2019 Salidroside Delays Cellular Senescence by Stimulating Mitochondrial Biogenesis Partly through a miR-22/SIRT-1 Pathway. rhodioloside 0-11 sirtuin 1 Homo sapiens 103-109 31612074-3 2019 Here, we reported that a component isolated from Rhodiola rosea L., salidroside, delays replicative senescence in human fibroblasts, which is related to its stimulation on mitochondrial biogenesis by activating SIRT1 partly resulted from inhibition on miR-22. rhodioloside 68-79 sirtuin 1 Homo sapiens 211-216 31612074-5 2019 SIRT1 is involved in the inducement of mitochondrial biogenesis by salidroside. rhodioloside 67-78 sirtuin 1 Homo sapiens 0-5 31612074-6 2019 The declined expression of SIRT1 in 50PD cells compared with the young 30PD cells was prevented upon salidroside treatment. rhodioloside 101-112 sirtuin 1 Homo sapiens 27-32 31612074-7 2019 In addition, pretreatment of EX-527, a selective SIRT1 inhibitor, could block the increased mitochondrial mass and decreased ROS production induced by salidroside in 50PD cells, resulting in an accelerated cellular senescence. rhodioloside 151-162 sirtuin 1 Homo sapiens 49-54 31612074-11 2019 Taken together, our data suggest that salidroside delays replicative senescence by stimulating mitochondrial biogenesis partly through a miR22/SIRT1 pathway, which enriches our current knowledge of a salidroside-mediated postpone senility effect and provides a new perspective on the antidecrepitude function of this naturally occurring compound in animals and humans. rhodioloside 38-49 sirtuin 1 Homo sapiens 143-148 31612074-11 2019 Taken together, our data suggest that salidroside delays replicative senescence by stimulating mitochondrial biogenesis partly through a miR22/SIRT1 pathway, which enriches our current knowledge of a salidroside-mediated postpone senility effect and provides a new perspective on the antidecrepitude function of this naturally occurring compound in animals and humans. rhodioloside 200-211 sirtuin 1 Homo sapiens 143-148 31146723-0 2019 Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway. rhodioloside 0-11 sirtuin 1 Homo sapiens 98-103 30942428-4 2019 Therefore, the purpose of the present study was to investigate the role of the adenosine monophosphate-activated protein kinase (AMPK)/sirtuin (SIRT)1 pathway in the protection of salidroside against ox-LDL-induced human umbilical vein endothelial cells (HUVECs) injuries. rhodioloside 180-191 sirtuin 1 Homo sapiens 144-150 31146723-17 2019 CONCLUSION: Salidroside shows protective effect on endothelial cell induced by ox-LDL, and the mechanisms might be related to autophagy induction via increasing SIRT1 and FoxO1 expressions. rhodioloside 12-23 sirtuin 1 Homo sapiens 161-166 28851138-11 2018 Taken together, these results indicated that SIRT1 contributes to the neuroprotection of salidroside against MPP+ -induced apoptosis and oxidative stress, in part through suppressing of mitogen-activated protein kinase (MAPK) pathways. rhodioloside 89-100 sirtuin 1 Homo sapiens 45-50 29434685-0 2018 Salidroside attenuates hypoxia/reoxygenation-induced human brain vascular smooth muscle cell injury by activating the SIRT1/FOXO3alpha pathway. rhodioloside 0-11 sirtuin 1 Homo sapiens 118-123 29434685-5 2018 Therefore, the present study aimed to investigate whether SAL protects human brain vascular smooth muscle cells (HBVSMC) against hypoxia/reoxygenation (H/R) injury, which is a cell model of cerebral ischemia-reperfusion injury, through regulating the SIRT1-activited signaling pathway. rhodioloside 58-61 sirtuin 1 Homo sapiens 251-256 29434685-8 2018 SAL attenuated the H/R-induced decrease in the expression of SIRT1 and phosphorylated FOXO3alpha protein in HBVSMCs, suggesting that the protective role of SAL in H/R injury occurs via the SIRT1/FOXO3alpha pathway. rhodioloside 0-3 sirtuin 1 Homo sapiens 61-66 29434685-8 2018 SAL attenuated the H/R-induced decrease in the expression of SIRT1 and phosphorylated FOXO3alpha protein in HBVSMCs, suggesting that the protective role of SAL in H/R injury occurs via the SIRT1/FOXO3alpha pathway. rhodioloside 0-3 sirtuin 1 Homo sapiens 189-194 29434685-9 2018 Furthermore, sirtinol, a SIRT1-specific inhibitor, suppressed the inhibitory effects of SAL on H/R-induced cytotoxicity and apoptosis as indicated by the downregulation of cell viability and upregulation of caspase-3 activity and apoptosis rate induced by sirtinol treatment in HBVSMCs. rhodioloside 88-91 sirtuin 1 Homo sapiens 25-30 28851138-0 2018 SIRT1 mediates salidroside-elicited protective effects against MPP+ -induced apoptosis and oxidative stress in SH-SY5Y cells: involvement in suppressing MAPK pathways. rhodioloside 15-26 sirtuin 1 Homo sapiens 0-5 28851138-5 2018 Hence, the present study investigated the roles of SIRT1 in neuroprotective effect of salidroside against N-methyl-4-phenylpyridinium (MPP+ )-induced SH-SY5Y cell injury. rhodioloside 86-97 sirtuin 1 Homo sapiens 51-56 28851138-7 2018 Simultaneously, salidroside pretreatment remarkably increased SIRT1 activity, SIRT1 mRNA and protein levels in MPP+ -treated SH-SY5Y cell. rhodioloside 16-27 sirtuin 1 Homo sapiens 62-67 28851138-7 2018 Simultaneously, salidroside pretreatment remarkably increased SIRT1 activity, SIRT1 mRNA and protein levels in MPP+ -treated SH-SY5Y cell. rhodioloside 16-27 sirtuin 1 Homo sapiens 78-83 28851138-8 2018 However, sirtinol, a SIRT1 activation inhibitor, significantly blocked the inhibitory effects of salidroside on MPP+ -induced cytotoxicity and apoptosis. rhodioloside 97-108 sirtuin 1 Homo sapiens 21-26 29434685-11 2018 These results suggest that SAL exhibits neuroprotective effects against H/R injury by activating the SIRT1/FOXO3alpha pathway, which may become a novel potential therapeutic target for the treatment of cerebral ischemic disease. rhodioloside 27-30 sirtuin 1 Homo sapiens 101-106