PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31920355-12 2019 Further investigation indicated that Salidroside down-regulated the mRNA expression of IL-1beta and IL-6-pro-inflammatory cytokines. rhodioloside 37-48 interleukin 6 Homo sapiens 100-104 31747547-8 2020 Furthermore, salidroside remarkably decreased the levels of the pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-6 and impeded the expression of VCAM-1 and ICAM-1 induced by AGEs. rhodioloside 13-24 interleukin 6 Homo sapiens 115-119 29960844-7 2018 Pretreatment with salidroside markedly inhibited the production levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in a dose-dependent manner. rhodioloside 18-29 interleukin 6 Homo sapiens 148-152 30944705-0 2019 Salidroside regulates the expressions of IL-6 and defensins in LPS-activated intestinal epithelial cells through NF-kappaB/MAPK and STAT3 pathways. rhodioloside 0-11 interleukin 6 Homo sapiens 41-45 30944705-6 2019 Results: Salidroside impaired the proliferation of intestinal epithelial cells at high concentrations (P< 0.05) and down-regulated interleukin-6 (IL-6) production induced by LPS (P<0.05). rhodioloside 9-20 interleukin 6 Homo sapiens 134-147 30944705-6 2019 Results: Salidroside impaired the proliferation of intestinal epithelial cells at high concentrations (P< 0.05) and down-regulated interleukin-6 (IL-6) production induced by LPS (P<0.05). rhodioloside 9-20 interleukin 6 Homo sapiens 149-153 30944705-9 2019 Conclusion: In summary, salidroside suppressed the expression of IL-6 and elevated the expression of defensins in LPS-activated intestinal epithelial cells through NF-kappaB/MAPK and STAT3 pathways. rhodioloside 24-35 interleukin 6 Homo sapiens 65-69 23904362-6 2013 The results showed that Sal significantly decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) at both mRNA and protein levels in THP-1-derived macrophages, and the effect was dose-depedent. rhodioloside 24-27 interleukin 6 Homo sapiens 165-178 27028995-7 2016 Ex vivo studies showed that salidroside has no toxicity to cells, and inhibits the production of PGE2, phosphorylation of p38 or JNKs, and secretion of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) caused by SUV irradiation. rhodioloside 28-39 interleukin 6 Homo sapiens 152-165 27028995-7 2016 Ex vivo studies showed that salidroside has no toxicity to cells, and inhibits the production of PGE2, phosphorylation of p38 or JNKs, and secretion of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) caused by SUV irradiation. rhodioloside 28-39 interleukin 6 Homo sapiens 167-171 25639473-10 2015 Additionally, salidroside significantly attenuated UVB-induced synthesis of MMP-1 as well as the production of IL-6 and TNF-alpha in HDFs. rhodioloside 14-25 interleukin 6 Homo sapiens 111-115 25341565-6 2014 Furthermore, salidroside attenuates the expression of intercellular adhesion molecule 1 and IL-6 through modulating the activities of p38 MAPK and NF-kappaB in the BEAS-2B cells stimulated by proinflammatory cytokines. rhodioloside 13-24 interleukin 6 Homo sapiens 92-96 23904362-6 2013 The results showed that Sal significantly decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) at both mRNA and protein levels in THP-1-derived macrophages, and the effect was dose-depedent. rhodioloside 24-27 interleukin 6 Homo sapiens 180-184 23904362-8 2013 The findings suggested that Sal can suppress the activation of LPS-stimulated PMA-differetiated THP-1 cells, as evidenced by the decreased expression of iNOS, COX2, IL-1beta, IL-6 and TNF-alpha, and the mechanism involves the inhibition of NF-kappaB activation and the phosphorylation of the MAPK signal pathway. rhodioloside 28-31 interleukin 6 Homo sapiens 175-179