PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34292604-6 2021 Mechanistically, integrated RNA sequencing and bioinformatic analysis showed that salidroside promoted AMPK signaling pathway activation in vitro and in vivo, and this finding was further verified by determining the phosphorylation levels of AMPK. rhodioloside 82-93 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 103-107 34813774-0 2022 Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN. rhodioloside 0-11 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 58-62 34813774-7 2022 Mechanistically, AMP-activated protein kinase (AMPK) was identified to be the upstream signaling involved in salidroside-induced Nrf2 activation, as silencing of AMPK partly prevented the upregulation of Nrf2 and the downstream proteins HO-1 and NQO1. rhodioloside 109-120 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 17-45 34813774-7 2022 Mechanistically, AMP-activated protein kinase (AMPK) was identified to be the upstream signaling involved in salidroside-induced Nrf2 activation, as silencing of AMPK partly prevented the upregulation of Nrf2 and the downstream proteins HO-1 and NQO1. rhodioloside 109-120 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 47-51 34813774-7 2022 Mechanistically, AMP-activated protein kinase (AMPK) was identified to be the upstream signaling involved in salidroside-induced Nrf2 activation, as silencing of AMPK partly prevented the upregulation of Nrf2 and the downstream proteins HO-1 and NQO1. rhodioloside 109-120 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 162-166 34813774-8 2022 Altogether, the present study is the first to effectively demonstrate the inhibitory effect of salidroside on DHT-stimulated oxidative stress and apoptosis in KGN cells, which was dependent on Nrf2 activation that involved AMPK. rhodioloside 95-106 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 223-227 34292604-6 2021 Mechanistically, integrated RNA sequencing and bioinformatic analysis showed that salidroside promoted AMPK signaling pathway activation in vitro and in vivo, and this finding was further verified by determining the phosphorylation levels of AMPK. rhodioloside 82-93 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 242-246 34292604-7 2021 Furthermore, the protective effects of salidroside on lipid accumulation and inflammation in hepatocytes and livers induced by PO- or HFHC- stimulation were blocked by AMPK interruption. rhodioloside 39-50 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 168-172 34292604-8 2021 CONCLUSION: Our studies demonstrate that salidroside protects against metabolic stress-induced NASH progression through activation of AMPK signaling, indicating that salidroside could be a potential new drug component for NASH therapy. rhodioloside 41-52 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 134-138 34634782-0 2022 Salidroside Mitigates Airway Inflammation in Asthmatic Mice via the AMPK/Akt/GSK3beta Signaling Pathway. rhodioloside 0-11 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 68-72 34634782-11 2022 Moreover, after the mice were treated with SAL, the phosphorylation level of AMPK was significantly increased, which further reduced the phosphorylation levels of Akt and GSK3beta (p < 0.05). rhodioloside 43-46 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 77-81 34634782-13 2022 CONCLUSION: SAL can inhibit bronchial hyperresponsiveness and reduce tracheal inflammation by increasing AMPK phosphorylation and inhibiting Akt and GSK3beta signaling pathways. rhodioloside 12-15 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 105-109 34457117-0 2021 Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation. rhodioloside 0-11 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 90-94 34457117-3 2021 It has been shown that SAL improves metabolic inflammation in diabetic rodents through AMP-activated protein kinase- (AMPK-) dependent inhibition of the NLRP3 inflammasome. rhodioloside 23-26 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 118-122 34457117-7 2021 Moreover, SAL protected A549 cells against LPS-induced AMPK inhibition, ROS production, and NLRP3 inflammasome activation. rhodioloside 10-13 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 55-59 34457117-8 2021 Blocking AMPK using Compound C almost completely suppressed the beneficial effects of SAL. rhodioloside 86-89 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 9-13 34457117-9 2021 In summary, these results indicate that SAL suppresses the proliferation and migration of human lung cancer cells through AMPK-dependent NLRP3 inflammasome regulation. rhodioloside 40-43 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 122-126