PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34813774-0	2022	Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.	rhodioloside	0-11	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	58-62	
34813774-7	2022	Mechanistically, AMP-activated protein kinase (AMPK) was identified to be the upstream signaling involved in salidroside-induced Nrf2 activation, as silencing of AMPK partly prevented the upregulation of Nrf2 and the downstream proteins HO-1 and NQO1.	rhodioloside	109-120	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	17-45	
34813774-7	2022	Mechanistically, AMP-activated protein kinase (AMPK) was identified to be the upstream signaling involved in salidroside-induced Nrf2 activation, as silencing of AMPK partly prevented the upregulation of Nrf2 and the downstream proteins HO-1 and NQO1.	rhodioloside	109-120	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	47-51	
34813774-7	2022	Mechanistically, AMP-activated protein kinase (AMPK) was identified to be the upstream signaling involved in salidroside-induced Nrf2 activation, as silencing of AMPK partly prevented the upregulation of Nrf2 and the downstream proteins HO-1 and NQO1.	rhodioloside	109-120	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	162-166	
34813774-8	2022	Altogether, the present study is the first to effectively demonstrate the inhibitory effect of salidroside on DHT-stimulated oxidative stress and apoptosis in KGN cells, which was dependent on Nrf2 activation that involved AMPK.	rhodioloside	95-106	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	223-227	
34634782-0	2022	Salidroside Mitigates Airway Inflammation in Asthmatic Mice via the AMPK/Akt/GSK3beta Signaling Pathway.	rhodioloside	0-11	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	68-72	
34634782-11	2022	Moreover, after the mice were treated with SAL, the phosphorylation level of AMPK was significantly increased, which further reduced the phosphorylation levels of Akt and GSK3beta (p < 0.05).	rhodioloside	43-46	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	77-81	
34634782-13	2022	CONCLUSION: SAL can inhibit bronchial hyperresponsiveness and reduce tracheal inflammation by increasing AMPK phosphorylation and inhibiting Akt and GSK3beta signaling pathways.	rhodioloside	12-15	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	105-109	
34292604-6	2021	Mechanistically, integrated RNA sequencing and bioinformatic analysis showed that salidroside promoted AMPK signaling pathway activation in vitro and in vivo, and this finding was further verified by determining the phosphorylation levels of AMPK.	rhodioloside	82-93	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	103-107	
34292604-6	2021	Mechanistically, integrated RNA sequencing and bioinformatic analysis showed that salidroside promoted AMPK signaling pathway activation in vitro and in vivo, and this finding was further verified by determining the phosphorylation levels of AMPK.	rhodioloside	82-93	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	242-246	
34292604-7	2021	Furthermore, the protective effects of salidroside on lipid accumulation and inflammation in hepatocytes and livers induced by PO- or HFHC- stimulation were blocked by AMPK interruption.	rhodioloside	39-50	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	168-172	
34292604-8	2021	CONCLUSION: Our studies demonstrate that salidroside protects against metabolic stress-induced NASH progression through activation of AMPK signaling, indicating that salidroside could be a potential new drug component for NASH therapy.	rhodioloside	41-52	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	134-138	
34457117-0	2021	Salidroside Suppresses the Proliferation and Migration of Human Lung Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation.	rhodioloside	0-11	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	90-94	
34457117-3	2021	It has been shown that SAL improves metabolic inflammation in diabetic rodents through AMP-activated protein kinase- (AMPK-) dependent inhibition of the NLRP3 inflammasome.	rhodioloside	23-26	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	118-122	
34457117-7	2021	Moreover, SAL protected A549 cells against LPS-induced AMPK inhibition, ROS production, and NLRP3 inflammasome activation.	rhodioloside	10-13	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	55-59	
34457117-8	2021	Blocking AMPK using Compound C almost completely suppressed the beneficial effects of SAL.	rhodioloside	86-89	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	9-13	
34457117-9	2021	In summary, these results indicate that SAL suppresses the proliferation and migration of human lung cancer cells through AMPK-dependent NLRP3 inflammasome regulation.	rhodioloside	40-43	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	122-126