PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22664423-0 2012 Salidroside protects PC12 cells from MPP+-induced apoptosis via activation of the PI3K/Akt pathway. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 87-90 22664423-6 2012 SAL enhanced Akt phosphorylation in PC12 cells, and the protective effects of SAL against MPP(+)-induced apoptosis were abolished by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K) phosphorylation. rhodioloside 0-3 AKT serine/threonine kinase 1 Rattus norvegicus 13-16 22664423-7 2012 These findings suggest that SAL prevents MPP(+)-induced apoptosis in PC12 cells, at least in part through activation of the PI3K/Akt pathway. rhodioloside 28-31 AKT serine/threonine kinase 1 Rattus norvegicus 129-132 32489291-0 2020 Mechanism of salidroside relieving the acute hypoxia-induced myocardial injury through the PI3K/Akt pathway. rhodioloside 13-24 AKT serine/threonine kinase 1 Rattus norvegicus 96-99 21563965-0 2011 Salidroside protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via PI3K-Akt dependent pathway. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 93-96 21563965-5 2011 Salidroside significantly augmented Akt phosphorylation at Serine 473 in the absence or presence of H2O2 stimulation; wortmannin, a specific inhibitor of PI3K, abrogated salidroside protection. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 36-39 21563965-7 2011 Our results indicated that salidroside protected cardiomyocytes against oxidative injury through activating the PI3K/Akt pathway and increasing the expression and activities of endogenous PI3K dependent antioxidant enzymes. rhodioloside 27-38 AKT serine/threonine kinase 1 Rattus norvegicus 117-120 21160132-5 2010 Salidroside administration also inhibited myocardial apoptosis in AMI rats by increasing phosphorylation of Akt and decreasing activation of caspase-3. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 108-111 18501890-5 2008 In addition, salidroside enhanced insulin-mediated Akt activation and glucose uptake, and such enhancement can be specifically inhibited by compound C. In summary, AMPK activation was involved in the effects of salidroside on glucose transport activation and insulin sensitivity. rhodioloside 13-24 AKT serine/threonine kinase 1 Rattus norvegicus 51-54 18501890-5 2008 In addition, salidroside enhanced insulin-mediated Akt activation and glucose uptake, and such enhancement can be specifically inhibited by compound C. In summary, AMPK activation was involved in the effects of salidroside on glucose transport activation and insulin sensitivity. rhodioloside 211-222 AKT serine/threonine kinase 1 Rattus norvegicus 51-54 34092295-0 2021 The bioinformatics and metabolomics research on anti-hypoxic molecular mechanisms of Salidroside via regulating the PTEN mediated PI3K/Akt/NF-kappaB signaling pathway. rhodioloside 85-96 AKT serine/threonine kinase 1 Rattus norvegicus 135-138 32767741-7 2020 The results showed that SAL and hypoxia treatments synergistically enhanced the viability (fold) and proliferation of rASCs under non-stressed conditions in association with increased autophagic flux and activation of Akt, Erk1/2 and LC3. rhodioloside 24-27 AKT serine/threonine kinase 1 Rattus norvegicus 218-221 32767741-9 2020 The SAL and hypoxia pre-treatment also enhanced the proliferation and migration of rASCs under oxidative stress in association with Akt and Erk1/2 activation; however, the combined pre-treatment exhibited a more profound enhancement in the migration than proliferation. rhodioloside 4-7 AKT serine/threonine kinase 1 Rattus norvegicus 132-135 32489291-1 2020 Objective: The objective was to investigate the anti-inflammatory effects of salidroside through the PI3K/Akt signaling pathway and its protective effects on acute hypoxia-induced myocardial injury in rats. rhodioloside 77-88 AKT serine/threonine kinase 1 Rattus norvegicus 106-109 32489291-22 2020 The application of salidroside could reduce the inflammatory responses of rats with hypobaric hypoxia-induced myocardial injuries through PI3K/Akt signaling pathway, thereby protecting the myocardial cells. rhodioloside 19-30 AKT serine/threonine kinase 1 Rattus norvegicus 143-146 29864934-13 2018 To conclude, this study provide in vitro evidence that salidroside protected NSCs against hypoxia-induced injury by up-regulation of miR-210, which in turn inhibited the expression of BTG3 and activated PI3K/AKT/mTOR signaling pathway. rhodioloside 55-66 AKT serine/threonine kinase 1 Rattus norvegicus 208-211 31440754-9 2019 In conclusion, Sal may directly inhibit LPS-induced inflammatory activation of AM (NR 8383), promote the proliferation of AEC II (RLE-6TN) through PI3K/AKT signaling pathway, and enhance the regulatory effect of AEC II on LPS-induced inflammatory activation of AM. rhodioloside 15-18 AKT serine/threonine kinase 1 Rattus norvegicus 152-155 31440754-6 2019 Compared with control group, 32 and 128 microg/mL Sal pretreatment significantly increased the ratio of p-AKT/AKT in RLE-6TN cells (P < 0.05). rhodioloside 50-53 AKT serine/threonine kinase 1 Rattus norvegicus 106-109 31440754-6 2019 Compared with control group, 32 and 128 microg/mL Sal pretreatment significantly increased the ratio of p-AKT/AKT in RLE-6TN cells (P < 0.05). rhodioloside 50-53 AKT serine/threonine kinase 1 Rattus norvegicus 110-113 30720058-0 2019 Salidroside protects PC-12 cells against amyloid beta-induced apoptosis by activation of the ERK1/2 and AKT signaling pathways. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 104-107 30720058-5 2019 Mechanistic studies demonstrated that salidroside significantly activated the extracellular signal regulated kinase (ERK)1/2 and protein kinase B (AKT) signaling pathways. rhodioloside 38-49 AKT serine/threonine kinase 1 Rattus norvegicus 147-150 30720058-6 2019 This observation was further confirmed using the ERK1/2 inhibitor PD98059 and the AKT inhibitor LY294002, which demonstrated that salidroside promoted PC-12 cell survival and proliferation by activating the ERK1/2 and AKT signaling pathways. rhodioloside 130-141 AKT serine/threonine kinase 1 Rattus norvegicus 82-85 30720058-6 2019 This observation was further confirmed using the ERK1/2 inhibitor PD98059 and the AKT inhibitor LY294002, which demonstrated that salidroside promoted PC-12 cell survival and proliferation by activating the ERK1/2 and AKT signaling pathways. rhodioloside 130-141 AKT serine/threonine kinase 1 Rattus norvegicus 218-221 29626425-0 2018 Salidroside improves brain ischemic injury by activating PI3K/Akt pathway and reduces complications induced by delayed tPA treatment. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 62-65 28465020-0 2017 Salidroside attenuates colistin-induced neurotoxicity in RSC96 Schwann cells through PI3K/Akt pathway. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 90-93 29286130-0 2018 Salidroside inhibits steroid-induced avascular necrosis of the femoral head via the PI3K/Akt signaling pathway: In vitro and in vivo studies. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 89-92 29286130-2 2018 Salidroside (Sal) has demonstrated an anti-apoptotic effect on neurocytes by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 143-146 29286130-2 2018 Salidroside (Sal) has demonstrated an anti-apoptotic effect on neurocytes by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. rhodioloside 0-3 AKT serine/threonine kinase 1 Rattus norvegicus 143-146 29286130-6 2018 Sal decreased the expression of cleaved caspase-3, cleaved caspase-9, apoptosis regulator BAX and cytochrome C, while it increased the expression of B cell lymphoma-2 and phosphorylated-Akt in Dex-induced osteoblasts. rhodioloside 0-3 AKT serine/threonine kinase 1 Rattus norvegicus 186-189 28905500-0 2017 Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K/Akt/mTOR pathway in vitro and in vivo. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 86-89 28478514-0 2017 Salidroside Inhibits Inflammation Through PI3K/Akt/HIF Signaling After Focal Cerebral Ischemia in Rats. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 47-50 28478514-4 2017 At the same time, salidroside increased the ratio of phosphorylated protein kinase B (p-Akt) to total Akt. rhodioloside 18-29 AKT serine/threonine kinase 1 Rattus norvegicus 88-91 28478514-4 2017 At the same time, salidroside increased the ratio of phosphorylated protein kinase B (p-Akt) to total Akt. rhodioloside 18-29 AKT serine/threonine kinase 1 Rattus norvegicus 102-105 28465020-4 2017 Salidroside could reduce colistin-induced neurotoxicity, decrease the effect of colistin on the reduced expression levels of p-Akt and Bcl-2, and increased the expresion of Bax, release of Cyt c, and activation of caspase-3. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 127-130 28465020-6 2017 These findings suggest that Salidroside could attenuate colistin-induced neurotoxicity in RSC96 Schwann cells via the PI3K/Akt pathway. rhodioloside 28-39 AKT serine/threonine kinase 1 Rattus norvegicus 123-126 27357827-10 2016 Salidroside inhibited the glutamate-induced dissociation of the Bcl-2-Beclin-1 complex with minor affects on the PI3K/Akt/mTOR signaling pathways. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 118-121 26104971-0 2015 Salidroside Mitigates Sepsis-Induced Myocarditis in Rats by Regulating IGF-1/PI3K/Akt/GSK-3beta Signaling. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 82-85 26104971-6 2015 Thus, Sal is assumed to exert pronounced cardioprotective effects in rats subjected to LPS, probably through regulation of IGF-1/PI3K/Akt/GSK-3beta signaling. rhodioloside 6-9 AKT serine/threonine kinase 1 Rattus norvegicus 134-137 24840151-7 2014 These results indicate that salidroside suppresses PDGF-BB-induced PASMC proliferation through the AKT/GSK3beta signaling pathway and suggests that it may be a feasible therapy for pulmonary vascular remodeling diseases. rhodioloside 28-39 AKT serine/threonine kinase 1 Rattus norvegicus 99-102 25063033-0 2014 Salidroside inhibits oxygen glucose deprivation (OGD)/re-oxygenation-induced H9c2 cell necrosis through activating of Akt-Nrf2 signaling. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 118-121 25063033-5 2014 Meanwhile, salidroside activated Akt and promoted transcription of NF-E2-related factor 2 (Nrf2)-regulated genes (heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO-1)). rhodioloside 11-22 AKT serine/threonine kinase 1 Rattus norvegicus 33-36 25063033-6 2014 Significantly, Nrf2 shRNA knockdown or Akt inhibitors (LY 294002 and wortmannin) not only prevented salidroside-induced HO-1/NQO-1 transcription, but also alleviated salidroside-mediated cytoprotective effect against OGD/re-oxygenation in H9c2 cells. rhodioloside 100-111 AKT serine/threonine kinase 1 Rattus norvegicus 39-42 25063033-6 2014 Significantly, Nrf2 shRNA knockdown or Akt inhibitors (LY 294002 and wortmannin) not only prevented salidroside-induced HO-1/NQO-1 transcription, but also alleviated salidroside-mediated cytoprotective effect against OGD/re-oxygenation in H9c2 cells. rhodioloside 166-177 AKT serine/threonine kinase 1 Rattus norvegicus 39-42 25063033-7 2014 These observations suggest that salidroside activates Nrf2-regulated anti-oxidant signaling, and protects against OGD/re-oxygenation-induced H9c2 cell necrosis via activation of Akt signaling. rhodioloside 32-43 AKT serine/threonine kinase 1 Rattus norvegicus 178-181 24840151-6 2014 Further experiments showed that the beneficial effect of salidroside on blocking the proliferation of PASMCs was associated with the suppression of the AKT/glycogen synthase kinase 3 beta (GSK3beta) signaling pathway, but did not involve the extracellular signal-regulated kinase 1/2, p38 and c-Jun-N-terminal kinase signaling pathways. rhodioloside 57-68 AKT serine/threonine kinase 1 Rattus norvegicus 152-155 24631136-10 2014 Salidroside treatment results in a slight activation in Akt, while no significant alteration in JNK activity was observed. rhodioloside 0-11 AKT serine/threonine kinase 1 Rattus norvegicus 56-59