PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29620198-6	2018	Pharmacological inhibition of HIF-1alpha activation by 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol (YC-1) markedly suppressed the enhanced expression of HIF-1alpha, disrupted NF-kappaB signaling pathway activity and inhibited the isoflurane-induced increase of TNF-1alpha expression.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	109-113	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	30-40	
33907819-13	2021	The inhibition of the HIF-1alpha/BNIP3 signaling pathway using 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (an inhibitor of HIF-1alpha) prevented the effects of naringin on the autophagic flux and reversed its protective effects against CoCl2-induced injury.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	63-109	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	22-32	
33869936-9	2021	Treatment with the HIF-1alpha inhibitor YC-1 reversed Rox-increased ALD A and GLUT1 levels and attenuated Rox-induced VEC viability, suggesting that Rox-induced HIF-1alpha contributes to the glycolytic and angiogenic effects of Rox.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	40-44	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	19-29	
33869936-9	2021	Treatment with the HIF-1alpha inhibitor YC-1 reversed Rox-increased ALD A and GLUT1 levels and attenuated Rox-induced VEC viability, suggesting that Rox-induced HIF-1alpha contributes to the glycolytic and angiogenic effects of Rox.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	40-44	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	161-171	
33907819-13	2021	The inhibition of the HIF-1alpha/BNIP3 signaling pathway using 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (an inhibitor of HIF-1alpha) prevented the effects of naringin on the autophagic flux and reversed its protective effects against CoCl2-induced injury.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	63-109	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	127-137	
29620198-6	2018	Pharmacological inhibition of HIF-1alpha activation by 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol (YC-1) markedly suppressed the enhanced expression of HIF-1alpha, disrupted NF-kappaB signaling pathway activity and inhibited the isoflurane-induced increase of TNF-1alpha expression.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	109-113	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	162-172	
27938560-0	2016	[Effect of targeted inhibition of hypoxia-inducible factor-1alpha by 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole on the progression of non-alcoholic fatty liver disease in rats].	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	69-115	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	34-65	
27938560-1	2016	Objective: To investigate the effect of targeted inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) by 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) on the progression of non-alcoholic fat liver diseases (NAFLD) in rats.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	111-157	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	63-94	
27938560-1	2016	Objective: To investigate the effect of targeted inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) by 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) on the progression of non-alcoholic fat liver diseases (NAFLD) in rats.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	111-157	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	96-106	
21239965-7	2011	To investigate the action of HIF-1alpha in the neuroprotective effects of orexin-A, the HIF-1alpha inhibitor YC-1 was used alone or combined with orexin-A.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	109-113	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	88-98	
19962996-7	2010	KEY FINDINGS: Renal HIF-1alpha and HSP70 expression were enhanced by hypoxic preconditioning and inhibited by the HIF-1alpha inhibitor, YC-1, as well as phosphatidylinositol 3-kinase (PI3K)/Akt inhibitors.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	136-140	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	20-30	
20224844-3	2010	HIF-1alpha activity was suppressed by treating the cells with 3-(5"-hydroxymethyl-2"- furyl)-1-benzyl indazole (YC-1).	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	62-110	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10	
28887194-7	2018	Pharmacological inhibition of HIF-1alpha activation by 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) markedly suppressed the expression of HIF-1alpha, VEGF and MMP-2, and mitigated the severity of BBB disruption.YC-1 pretreatment also significantly attenuated isoflurane-induced cognitive deficits in the Morris water maze task.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	55-101	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	30-40	
28887194-7	2018	Pharmacological inhibition of HIF-1alpha activation by 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) markedly suppressed the expression of HIF-1alpha, VEGF and MMP-2, and mitigated the severity of BBB disruption.YC-1 pretreatment also significantly attenuated isoflurane-induced cognitive deficits in the Morris water maze task.	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	55-101	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	147-157