PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33907819-13 2021 The inhibition of the HIF-1alpha/BNIP3 signaling pathway using 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (an inhibitor of HIF-1alpha) prevented the effects of naringin on the autophagic flux and reversed its protective effects against CoCl2-induced injury. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 63-109 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 22-32 21239965-7 2011 To investigate the action of HIF-1alpha in the neuroprotective effects of orexin-A, the HIF-1alpha inhibitor YC-1 was used alone or combined with orexin-A. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 109-113 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 88-98 33907819-13 2021 The inhibition of the HIF-1alpha/BNIP3 signaling pathway using 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (an inhibitor of HIF-1alpha) prevented the effects of naringin on the autophagic flux and reversed its protective effects against CoCl2-induced injury. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 63-109 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 127-137 19962996-7 2010 KEY FINDINGS: Renal HIF-1alpha and HSP70 expression were enhanced by hypoxic preconditioning and inhibited by the HIF-1alpha inhibitor, YC-1, as well as phosphatidylinositol 3-kinase (PI3K)/Akt inhibitors. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 136-140 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 20-30 20224844-3 2010 HIF-1alpha activity was suppressed by treating the cells with 3-(5"-hydroxymethyl-2"- furyl)-1-benzyl indazole (YC-1). 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 62-110 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 0-10 29620198-6 2018 Pharmacological inhibition of HIF-1alpha activation by 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol (YC-1) markedly suppressed the enhanced expression of HIF-1alpha, disrupted NF-kappaB signaling pathway activity and inhibited the isoflurane-induced increase of TNF-1alpha expression. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 109-113 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 30-40 33869936-9 2021 Treatment with the HIF-1alpha inhibitor YC-1 reversed Rox-increased ALD A and GLUT1 levels and attenuated Rox-induced VEC viability, suggesting that Rox-induced HIF-1alpha contributes to the glycolytic and angiogenic effects of Rox. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 40-44 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 19-29 33869936-9 2021 Treatment with the HIF-1alpha inhibitor YC-1 reversed Rox-increased ALD A and GLUT1 levels and attenuated Rox-induced VEC viability, suggesting that Rox-induced HIF-1alpha contributes to the glycolytic and angiogenic effects of Rox. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 40-44 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 161-171 29620198-6 2018 Pharmacological inhibition of HIF-1alpha activation by 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol (YC-1) markedly suppressed the enhanced expression of HIF-1alpha, disrupted NF-kappaB signaling pathway activity and inhibited the isoflurane-induced increase of TNF-1alpha expression. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 109-113 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 162-172 28887194-7 2018 Pharmacological inhibition of HIF-1alpha activation by 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) markedly suppressed the expression of HIF-1alpha, VEGF and MMP-2, and mitigated the severity of BBB disruption.YC-1 pretreatment also significantly attenuated isoflurane-induced cognitive deficits in the Morris water maze task. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 55-101 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 30-40 28887194-7 2018 Pharmacological inhibition of HIF-1alpha activation by 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) markedly suppressed the expression of HIF-1alpha, VEGF and MMP-2, and mitigated the severity of BBB disruption.YC-1 pretreatment also significantly attenuated isoflurane-induced cognitive deficits in the Morris water maze task. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 55-101 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 147-157 27938560-0 2016 [Effect of targeted inhibition of hypoxia-inducible factor-1alpha by 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole on the progression of non-alcoholic fatty liver disease in rats]. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 69-115 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 34-65 27938560-1 2016 Objective: To investigate the effect of targeted inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) by 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) on the progression of non-alcoholic fat liver diseases (NAFLD) in rats. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 111-157 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 63-94 27938560-1 2016 Objective: To investigate the effect of targeted inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) by 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) on the progression of non-alcoholic fat liver diseases (NAFLD) in rats. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 111-157 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 96-106