PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34457047-8 2021 The inhibition of HIF-1alpha by inhibitor YC-1 reduced demethylation in KG-1 cells by decreasing TET2 expression. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 42-46 hypoxia inducible factor 1 subunit alpha Homo sapiens 18-28 17312464-1 2007 OBJECTIVES: To investigate the effects of 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (YC-1) on HIF-1-driven transcription activity, cell proliferative vitality, and apoptosis in hypoxic human pancreatic cancer cells. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 42-89 hypoxia inducible factor 1 subunit alpha Homo sapiens 100-105 16024616-7 2005 The hypoxia responsiveness of this construct can be blocked by treatment with agents that affect the HIF-1alpha pathways, including topotecan, 1-benzyl-3-(5"-hydroxymethyl-2"-furyl)indazole (YC-1), and flavopiridol. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 191-195 hypoxia inducible factor 1 subunit alpha Homo sapiens 101-111 34623134-6 2021 An HIF-1alpha inhibitor, Lificiguat (YC-1) was synthesized as a chemodrug and codelivered with poly-porphyrins to decrease the expression of HIF-1alpha and inhibit tumor growth under hypoxia. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 25-35 hypoxia inducible factor 1 subunit alpha Homo sapiens 3-13 34623134-6 2021 An HIF-1alpha inhibitor, Lificiguat (YC-1) was synthesized as a chemodrug and codelivered with poly-porphyrins to decrease the expression of HIF-1alpha and inhibit tumor growth under hypoxia. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 25-35 hypoxia inducible factor 1 subunit alpha Homo sapiens 141-151 30881515-4 2019 The present study selected 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) and dimethyloxalylglycine (DMOG) as a HIF-1 signaling pathway inhibitor and activator, respectively, on HCC827 cells. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 27-73 hypoxia inducible factor 1 subunit alpha Homo sapiens 119-124 30939201-7 2019 In addition, the use of a widely used HIF-1alpha inhibitor, the 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1), prevented the rhFSH effect on the onset of MDR. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 64-110 hypoxia inducible factor 1 subunit alpha Homo sapiens 38-48 30939201-7 2019 In addition, the use of a widely used HIF-1alpha inhibitor, the 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1), prevented the rhFSH effect on the onset of MDR. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 112-116 hypoxia inducible factor 1 subunit alpha Homo sapiens 38-48 30046956-8 2019 Additionally, the Hif-1 alpha inhibitor 3-5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1), potently suppressed cell invasion and migration as well as expression of EMT in hypoxia-induced HepG2 cells. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 40-85 hypoxia inducible factor 1 subunit alpha Homo sapiens 18-29 32239594-6 2020 What"s more, the use of 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) further proved that PMS inhibited the malignant biological behaviors of HepG2 cells under hypoxic condition by suppressing the hypoxia-inducible factor 1 alpha (HIF-1alpha) expression. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 72-76 hypoxia inducible factor 1 subunit alpha Homo sapiens 205-237 32239594-6 2020 What"s more, the use of 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) further proved that PMS inhibited the malignant biological behaviors of HepG2 cells under hypoxic condition by suppressing the hypoxia-inducible factor 1 alpha (HIF-1alpha) expression. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 72-76 hypoxia inducible factor 1 subunit alpha Homo sapiens 239-249 31659886-7 2019 VEGF is a target gene of HIF-1alpha, and the increased expression of VEGF and RUNX2 proteins was enhanced by cobalt chloride (CoCl2, 100 mumol/L), an agonist of HIF-1alpha, and suppressed by 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (YC-1, 10 mumol/L), an antagonist of HIF-1alpha. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 191-238 hypoxia inducible factor 1 subunit alpha Homo sapiens 25-35 31659886-7 2019 VEGF is a target gene of HIF-1alpha, and the increased expression of VEGF and RUNX2 proteins was enhanced by cobalt chloride (CoCl2, 100 mumol/L), an agonist of HIF-1alpha, and suppressed by 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (YC-1, 10 mumol/L), an antagonist of HIF-1alpha. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 240-244 hypoxia inducible factor 1 subunit alpha Homo sapiens 25-35 30676731-5 2019 We subsequently found that a combination of DFO and the HIF1alpha inhibitor, lificiguat (also named YC1), significantly enhanced the antitumor efficacy of DFO in vitro. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 77-87 hypoxia inducible factor 1 subunit alpha Homo sapiens 56-65 28260147-12 2017 The HIF-1alpha inhibitor YC-1 partially inhibited hypoxia-induced VEGF secretion in ZK-1 cells. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 25-29 hypoxia inducible factor 1 subunit alpha Homo sapiens 4-14 29344650-15 2018 The effect of the delayed RIPC to reduce IR-induced renal damage and increase ADM expression was enhanced by HIF-1alpha agonists DMOG and BAY 85-3934, whereas the effect was whittled by HIF-1alpha antagonists YC-1 and 2-MeOE2. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 209-213 hypoxia inducible factor 1 subunit alpha Homo sapiens 186-196 28978999-2 2017 YC-1 is a HIF-1alpha inhibitor, and we revealed that low-dose YC-1 (10 microM) suppressed HIF-1alpha expression, and induced hypoxia-dependent apoptosis in the GC cell line 58As9. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 0-4 hypoxia inducible factor 1 subunit alpha Homo sapiens 10-20 24549370-4 2014 The suppression of HIF-1alpha with its inhibitor 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) in VHL-silenced 3AO cells antagonized the pro-migratory activity induced by the VHL deficiency and reversed the upregulation of MMP2, MMP9, HIF-1alpha and miR-210; however, it had no obvious effect on the VHL protein level. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 49-95 hypoxia inducible factor 1 subunit alpha Homo sapiens 19-29 26711814-7 2015 Tempol, YC-1 (HIF-1 inhibitor), and Bay 11-7082 (NF-kappaB inhibitor) suppressed the cycling hypoxia-mediated Bcl-xL induction in vitro and in vivo. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 8-12 hypoxia inducible factor 1 subunit alpha Homo sapiens 14-19 25824695-12 2015 In addition, groups of cells treated with 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole, which inhibits the expression of HIF-1alpha in hypoxia, contributed to the inhibited expression of HIF-1alpha and enhanced expression of C/EBPalpha in hypoxic bladder cancer cells. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 42-88 hypoxia inducible factor 1 subunit alpha Homo sapiens 123-133 25824695-12 2015 In addition, groups of cells treated with 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole, which inhibits the expression of HIF-1alpha in hypoxia, contributed to the inhibited expression of HIF-1alpha and enhanced expression of C/EBPalpha in hypoxic bladder cancer cells. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 42-88 hypoxia inducible factor 1 subunit alpha Homo sapiens 189-199 25781495-8 2015 The IPC-induced up-regulation of renalase in vivo was also reduced by pre-treatment with an HIF-1alpha inhibitor, 3-(5"-Hydroxymethyl-2"-furyl)-1-benzyl indazole. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 114-161 hypoxia inducible factor 1 subunit alpha Homo sapiens 92-102 24549370-4 2014 The suppression of HIF-1alpha with its inhibitor 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) in VHL-silenced 3AO cells antagonized the pro-migratory activity induced by the VHL deficiency and reversed the upregulation of MMP2, MMP9, HIF-1alpha and miR-210; however, it had no obvious effect on the VHL protein level. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 49-95 hypoxia inducible factor 1 subunit alpha Homo sapiens 243-253 23311761-6 2013 Anti-HIF-1alpha compound, 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) and NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), decreased hypoxic induction of SDF-1, and PDTC pretreatment cancelled HIF-1alpha expression as well, thus NPC migration induced by ACM was decreased accordingly. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 26-72 hypoxia inducible factor 1 subunit alpha Homo sapiens 5-15 24304276-2 2014 In a series of experimentations, using human thyroid cancer cells, we observed that estrogen and hypoxia modulate the hypoxia inducible factor-1 (HIF-1) signaling which is abrogated by the anti-estrogen fulvestrant and the HIF-1 inhibitor YC-1 (3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole). 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 245-291 hypoxia inducible factor 1 subunit alpha Homo sapiens 118-144 24304276-2 2014 In a series of experimentations, using human thyroid cancer cells, we observed that estrogen and hypoxia modulate the hypoxia inducible factor-1 (HIF-1) signaling which is abrogated by the anti-estrogen fulvestrant and the HIF-1 inhibitor YC-1 (3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole). 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 245-291 hypoxia inducible factor 1 subunit alpha Homo sapiens 146-151 23311761-6 2013 Anti-HIF-1alpha compound, 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) and NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC), decreased hypoxic induction of SDF-1, and PDTC pretreatment cancelled HIF-1alpha expression as well, thus NPC migration induced by ACM was decreased accordingly. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 26-72 hypoxia inducible factor 1 subunit alpha Homo sapiens 210-220 23123638-5 2013 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1), a novel anticancer drug initially developed as an inhibitor of HIF-1alpha, is currently undergoing preclinical trials against various forms of cancer. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 0-46 hypoxia inducible factor 1 subunit alpha Homo sapiens 118-128 23088607-4 2012 RESULTS: Using the murine mammary cell line TG1-1 we observed estrogen (E2) lead to an up regulation of hypoxia inducible factor-1 (HIF-1), an effect abrogated by the anti-estrogen Fulvestrant and the HIF-1 inhibitor YC-1 (3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole) suggesting the interchangeability of hypoxia and estrogen mediated effects. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 217-221 hypoxia inducible factor 1 subunit alpha Homo sapiens 132-137 23088607-4 2012 RESULTS: Using the murine mammary cell line TG1-1 we observed estrogen (E2) lead to an up regulation of hypoxia inducible factor-1 (HIF-1), an effect abrogated by the anti-estrogen Fulvestrant and the HIF-1 inhibitor YC-1 (3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole) suggesting the interchangeability of hypoxia and estrogen mediated effects. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 223-269 hypoxia inducible factor 1 subunit alpha Homo sapiens 132-137 22087807-11 2012 VEGF-A transcript expression was upregulated by LPS under both normoxia and hypoxia but was downregulated by pretreatment with TLR4-neutralizing antibody or the specific HIF-1alpha inhibitor 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 191-238 hypoxia inducible factor 1 subunit alpha Homo sapiens 170-180 20977428-3 2011 Recently, YC-1 [3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole] has been widely used as a potential HIF-1alpha inhibitor and is being developed as a novel anticancer drug. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 16-62 hypoxia inducible factor 1 subunit alpha Homo sapiens 100-110 22507221-1 2012 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (YC-1), the hypoxia-inducible factor-1 alpha (HIF-1alpha) inhibitor, suppresses tumor proliferation and metastasis by down-regulating HIF-1alpha expression under hypoxic conditions. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 0-47 hypoxia inducible factor 1 subunit alpha Homo sapiens 60-92 22507221-1 2012 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (YC-1), the hypoxia-inducible factor-1 alpha (HIF-1alpha) inhibitor, suppresses tumor proliferation and metastasis by down-regulating HIF-1alpha expression under hypoxic conditions. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 0-47 hypoxia inducible factor 1 subunit alpha Homo sapiens 94-104 22507221-1 2012 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (YC-1), the hypoxia-inducible factor-1 alpha (HIF-1alpha) inhibitor, suppresses tumor proliferation and metastasis by down-regulating HIF-1alpha expression under hypoxic conditions. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 0-47 hypoxia inducible factor 1 subunit alpha Homo sapiens 182-192 22217342-10 2012 Finally, HIF-1alpha inhibition either by incubating cells with 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (a widely used HIF-1alpha inhibitor) or by transfecting cells with specific siRNA for HIF-1alpha significantly decreased the expression of Pgp on the surface of cells and increased the intracellular doxorubicin accumulation in MCF7 3-D spheroids. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 63-109 hypoxia inducible factor 1 subunit alpha Homo sapiens 9-19 22217342-10 2012 Finally, HIF-1alpha inhibition either by incubating cells with 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (a widely used HIF-1alpha inhibitor) or by transfecting cells with specific siRNA for HIF-1alpha significantly decreased the expression of Pgp on the surface of cells and increased the intracellular doxorubicin accumulation in MCF7 3-D spheroids. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 63-109 hypoxia inducible factor 1 subunit alpha Homo sapiens 125-135 22217342-10 2012 Finally, HIF-1alpha inhibition either by incubating cells with 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (a widely used HIF-1alpha inhibitor) or by transfecting cells with specific siRNA for HIF-1alpha significantly decreased the expression of Pgp on the surface of cells and increased the intracellular doxorubicin accumulation in MCF7 3-D spheroids. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 63-109 hypoxia inducible factor 1 subunit alpha Homo sapiens 125-135 21523559-12 2011 The sst(1) downregulation, but not the sst(4) upregulation, was prevented by SU1498, S3I-201 or YC-1, an inhibitor of HIF-1alpha. 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole 96-100 hypoxia inducible factor 1 subunit alpha Homo sapiens 118-128