PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24395092-6	2014	PB strikingly inhibited MPP(+)-induced mitochondrial dysfunctions, including lowered membrane potential, decreased Bcl-2/Bax ratio, and the release of cytochrome c.	pinocembrin	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	121-124	
25377066-4	2015	Results indicate that pretreatment with PB for 4 h significantly reduced the 6-OHDA-induced cell viability loss, apoptotic rate and decreased Bcl-2/Bax ratio.	pinocembrin	40-42	BCL2 associated X, apoptosis regulator	Homo sapiens	148-151	
34336656-7	2021	PCB downregulated the expression levels of proteins involved in cell cycle progression and apoptosis, including cyclinB1, Cdc2, PARP1, Bcl-2, and survivin, and upregulated protein levels of cleaved PARP1, cleaved caspase3, cleaved caspase9, and BAX.	pinocembrin	0-3	BCL2 associated X, apoptosis regulator	Homo sapiens	245-248	
17186548-0	2007	Pinocembrin triggers Bax-dependent mitochondrial apoptosis in colon cancer cells.	pinocembrin	0-11	BCL2 associated X, apoptosis regulator	Homo sapiens	21-24	
17186548-7	2007	Overexpression of proapoptotic Bax protein sensitized the colon cancer cells to pinocembrin-induced apoptosis and Bax knockout cells were resistant to pinocembrin-induced apoptosis.	pinocembrin	80-91	BCL2 associated X, apoptosis regulator	Homo sapiens	31-34	
17186548-7	2007	Overexpression of proapoptotic Bax protein sensitized the colon cancer cells to pinocembrin-induced apoptosis and Bax knockout cells were resistant to pinocembrin-induced apoptosis.	pinocembrin	151-162	BCL2 associated X, apoptosis regulator	Homo sapiens	31-34	
17186548-7	2007	Overexpression of proapoptotic Bax protein sensitized the colon cancer cells to pinocembrin-induced apoptosis and Bax knockout cells were resistant to pinocembrin-induced apoptosis.	pinocembrin	151-162	BCL2 associated X, apoptosis regulator	Homo sapiens	114-117	
18625218-0	2008	Pinocembrin prevents glutamate-induced apoptosis in SH-SY5Y neuronal cells via decrease of bax/bcl-2 ratio.	pinocembrin	0-11	BCL2 associated X, apoptosis regulator	Homo sapiens	91-94	
18625218-8	2008	Western blotting results indicated that pinocembrin treatment reduced the expression of Bax and had no effect on Bcl-2, thus decreased the Bax-Bcl-2 ratio, which is in consistent with the gene expression result.	pinocembrin	40-51	BCL2 associated X, apoptosis regulator	Homo sapiens	88-91	
18625218-8	2008	Western blotting results indicated that pinocembrin treatment reduced the expression of Bax and had no effect on Bcl-2, thus decreased the Bax-Bcl-2 ratio, which is in consistent with the gene expression result.	pinocembrin	40-51	BCL2 associated X, apoptosis regulator	Homo sapiens	139-142	
18625218-10	2008	Thus we conclude that pinocembrin exerts its neuroprotective effects in glutamate injury model partly by inhibiting p53 expression, thus Bax-Bcl-2 ratio, and the release of cytochrome c.	pinocembrin	22-33	BCL2 associated X, apoptosis regulator	Homo sapiens	137-140	
27696114-5	2017	PB (25 muM) pretreatment (for 4 h) downregulated the levels of Bcl-2-associated X protein (Bax), blocked the release of cytochrome c to the cytosol, and inhibited the PQ-induced activation of caspase-9 and caspase-3.	pinocembrin	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	63-89	
27696114-5	2017	PB (25 muM) pretreatment (for 4 h) downregulated the levels of Bcl-2-associated X protein (Bax), blocked the release of cytochrome c to the cytosol, and inhibited the PQ-induced activation of caspase-9 and caspase-3.	pinocembrin	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	91-94	
27538638-6	2016	PCB strikingly inhibited Abeta25-35-induced mitochondrial dysfunctions, including lowered membrane potential, decreased Bcl-2/Bax ratio.	pinocembrin	0-3	BCL2 associated X, apoptosis regulator	Homo sapiens	126-129