PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32558923-9 2020 In conclusion, high-dose esomeprazole can cause strong inhibition of CYP2C19, but only weakly inhibits CYP3A4 and leads to minor induction of CYP1A2. Esomeprazole 25-37 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 142-148 32558923-0 2020 Effect of High-Dose Esomeprazole on CYP1A2, CYP2C19 and CYP3A4 Activities in Humans: Evidence for Substantial and Long-lasting Inhibition of CYP2C19. Esomeprazole 20-32 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 36-42 29027194-2 2018 The aim of this study was to characterize the pediatric predictive performance of the PBPK approach for 10 drugs extensively metabolized by CYP1A2 (theophylline), CYP2C8 (desloratidine, montelukast), CYP2C9 (diclofenac), CYP2C19 (esomeprazole, lansoprazole), CYP2D6 (tramadol), and CYP3A4 (itraconazole, ondansetron, sufentanil). Esomeprazole 230-242 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 140-146