PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29720497-4 2018 In OAT1 stably transfected human embryonic kidney 293 cells, the Km value of tenofovir for human OAT1 (hOAT1) was significantly lower than for OAT1 orthologs from common preclinical animals, including cynomolgus monkey, mouse, rat, and dog. Tenofovir 77-86 solute carrier family 22 member 6 Homo sapiens 3-7 29980578-7 2018 This was most probably attributable to specific uptake of CDDP by the organic cation transporter 2 (OCT2), TFV through organic anion transporter 1 (OAT1), and CsA competing for P-glycoprotein-mediated efflux. Tenofovir 107-110 solute carrier family 22 member 6 Homo sapiens 119-146 29980578-7 2018 This was most probably attributable to specific uptake of CDDP by the organic cation transporter 2 (OCT2), TFV through organic anion transporter 1 (OAT1), and CsA competing for P-glycoprotein-mediated efflux. Tenofovir 107-110 solute carrier family 22 member 6 Homo sapiens 148-152 29720497-4 2018 In OAT1 stably transfected human embryonic kidney 293 cells, the Km value of tenofovir for human OAT1 (hOAT1) was significantly lower than for OAT1 orthologs from common preclinical animals, including cynomolgus monkey, mouse, rat, and dog. Tenofovir 77-86 solute carrier family 22 member 6 Homo sapiens 97-101 29720497-4 2018 In OAT1 stably transfected human embryonic kidney 293 cells, the Km value of tenofovir for human OAT1 (hOAT1) was significantly lower than for OAT1 orthologs from common preclinical animals, including cynomolgus monkey, mouse, rat, and dog. Tenofovir 77-86 solute carrier family 22 member 6 Homo sapiens 103-108 29720497-4 2018 In OAT1 stably transfected human embryonic kidney 293 cells, the Km value of tenofovir for human OAT1 (hOAT1) was significantly lower than for OAT1 orthologs from common preclinical animals, including cynomolgus monkey, mouse, rat, and dog. Tenofovir 77-86 solute carrier family 22 member 6 Homo sapiens 97-101 25448811-3 2015 We show here that three antiviral drugs, adefovir, cidofovir and tenofovir exhibit significantly increased cytotoxicity in HEK293 cells transfected with organic anion transporter (OAT) 1 and 3 compared to a lack of cytotoxicity in HEK293 wildtype cells. Tenofovir 65-74 solute carrier family 22 member 6 Homo sapiens 153-192 26821801-11 2016 Functional OAT1 was directly responsible for cytotoxicity of adefovir, cidofovir, and tenofovir, while a drug interaction with zidovudine was not associated with decreased cell viability. Tenofovir 86-95 solute carrier family 22 member 6 Homo sapiens 11-15 24699134-2 2014 Tenofovir released from TDF undergoes active renal secretion via organic anion transporters (OAT1 and OAT3), leading to higher exposure of renal proximal tubules to tenofovir and a potential for renal adverse effects in a small subset of TDF-treated patients. Tenofovir 0-9 solute carrier family 22 member 6 Homo sapiens 93-97 24699134-2 2014 Tenofovir released from TDF undergoes active renal secretion via organic anion transporters (OAT1 and OAT3), leading to higher exposure of renal proximal tubules to tenofovir and a potential for renal adverse effects in a small subset of TDF-treated patients. Tenofovir 165-174 solute carrier family 22 member 6 Homo sapiens 93-97 24699134-2 2014 Tenofovir released from TDF undergoes active renal secretion via organic anion transporters (OAT1 and OAT3), leading to higher exposure of renal proximal tubules to tenofovir and a potential for renal adverse effects in a small subset of TDF-treated patients. Tenofovir 24-27 solute carrier family 22 member 6 Homo sapiens 93-97 24699134-5 2014 RESULTS: While OAT1 and OAT3 expression increased tenofovir cellular uptake by >70-fold and 8.2-fold, respectively, the expression of either OAT did not significantly change TAF intracellular accumulation under identical conditions. Tenofovir 50-59 solute carrier family 22 member 6 Homo sapiens 15-19 24699134-6 2014 In addition, although tenofovir was significantly more cytotoxic in OAT1- and OAT3-expressing cells (>21 and >3.6 fold change in CC50 values, respectively), TAF in vitro cytotoxicity showed little to no change upon overexpression of either renal transporter (0.5-3.5 fold change in CC50). Tenofovir 22-31 solute carrier family 22 member 6 Homo sapiens 68-72 24343710-2 2014 We hypothesized drug transporter expression in vaginal, cervical, and colorectal tissues is a contributing factor and selected 3 efflux (ABCB1/MDR1, ABCC2/MRP2, ABCC4/MRP4) and 3 uptake (SLC22A6/OAT1, SLC22A8/OAT3, SLCO1B1/OATP1B1) transporters to further investigate based on their affinity for 2 ARVs central to prevention (tenofovir, maraviroc). Tenofovir 326-335 solute carrier family 22 member 6 Homo sapiens 187-194 24343710-2 2014 We hypothesized drug transporter expression in vaginal, cervical, and colorectal tissues is a contributing factor and selected 3 efflux (ABCB1/MDR1, ABCC2/MRP2, ABCC4/MRP4) and 3 uptake (SLC22A6/OAT1, SLC22A8/OAT3, SLCO1B1/OATP1B1) transporters to further investigate based on their affinity for 2 ARVs central to prevention (tenofovir, maraviroc). Tenofovir 326-335 solute carrier family 22 member 6 Homo sapiens 195-199 21403643-5 2011 In this study, the role(s) of organic anion transporter type 1 (OAT1) and multidrug-resistant protein type 4 (MRP4) in transport and regulation of tenofovir in proximal tubules were assessed. Tenofovir 147-156 solute carrier family 22 member 6 Homo sapiens 30-62 23896476-2 2013 COBI and TFV have been reported to interact with distinct transporters in renal proximal tubules; while TFV is renally eliminated by a combination of glomerular filtration and tubular secretion via anion transporters OAT1, OAT3, and MRP4, COBI inhibits renal cation transporters, particularly MATE1, resulting in a measurable decrease in the tubular secretion of creatinine. Tenofovir 104-107 solute carrier family 22 member 6 Homo sapiens 217-221 21403643-5 2011 In this study, the role(s) of organic anion transporter type 1 (OAT1) and multidrug-resistant protein type 4 (MRP4) in transport and regulation of tenofovir in proximal tubules were assessed. Tenofovir 147-156 solute carrier family 22 member 6 Homo sapiens 64-68 21403643-14 2011 Both OAT1 and MRP4 have a direct role in transport and efflux of tenofovir, regulating levels of tenofovir in proximal tubules. Tenofovir 65-74 solute carrier family 22 member 6 Homo sapiens 5-9 21403643-14 2011 Both OAT1 and MRP4 have a direct role in transport and efflux of tenofovir, regulating levels of tenofovir in proximal tubules. Tenofovir 97-106 solute carrier family 22 member 6 Homo sapiens 5-9 21403643-15 2011 Disruption of OAT1 activity prevents tenofovir toxicity but loss of MRP4 can lead to increased renal proximal tubular toxicity. Tenofovir 37-46 solute carrier family 22 member 6 Homo sapiens 14-18 17372702-0 2007 Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Tenofovir 44-53 solute carrier family 22 member 6 Homo sapiens 80-85 21078936-0 2011 Raltegravir is a substrate for SLC22A6: a putative mechanism for the interaction between raltegravir and tenofovir. Tenofovir 105-114 solute carrier family 22 member 6 Homo sapiens 31-38 21078936-9 2011 Tenofovir and raltegravir competed for SLC22A6 transport in a concentration-dependent manner. Tenofovir 0-9 solute carrier family 22 member 6 Homo sapiens 39-46 17372702-9 2007 CONCLUSION: These results indicate that adefovir, cidofovir and tenofovir are substrates of hOAT3 as well as hOAT1, but that quantitatively hOAT1 is the major renal transporter for these drugs. Tenofovir 64-73 solute carrier family 22 member 6 Homo sapiens 109-114 34432302-7 2022 RESULTS: PAS inhibited OAT1- and OAT3-mediated tenofovir uptake in vitro. Tenofovir 47-56 solute carrier family 22 member 6 Homo sapiens 23-27 17503669-1 2007 BACKGROUND: Active renal secretion of tenofovir (TFV) across proximal tubules occurs via uptake by human organic anion transporters 1 and 3 (hOAT1 and hOAT3) coupled with efflux by multidrug resistance protein 4 (MRP4). Tenofovir 38-47 solute carrier family 22 member 6 Homo sapiens 105-139 17503669-1 2007 BACKGROUND: Active renal secretion of tenofovir (TFV) across proximal tubules occurs via uptake by human organic anion transporters 1 and 3 (hOAT1 and hOAT3) coupled with efflux by multidrug resistance protein 4 (MRP4). Tenofovir 38-47 solute carrier family 22 member 6 Homo sapiens 141-146 17503669-1 2007 BACKGROUND: Active renal secretion of tenofovir (TFV) across proximal tubules occurs via uptake by human organic anion transporters 1 and 3 (hOAT1 and hOAT3) coupled with efflux by multidrug resistance protein 4 (MRP4). Tenofovir 49-52 solute carrier family 22 member 6 Homo sapiens 105-139 17503669-1 2007 BACKGROUND: Active renal secretion of tenofovir (TFV) across proximal tubules occurs via uptake by human organic anion transporters 1 and 3 (hOAT1 and hOAT3) coupled with efflux by multidrug resistance protein 4 (MRP4). Tenofovir 49-52 solute carrier family 22 member 6 Homo sapiens 141-146 17005808-9 2006 On the basis of these and previous results, the molecular transport pathway for the active tubular secretion of TFV through renal proximal-tubule cells involves uptake from the blood mediated by human organic anion transporters 1 and 3 and efflux into urine by MRP4. Tenofovir 112-115 solute carrier family 22 member 6 Homo sapiens 201-235 15914676-8 2005 Interestingly, the K(m) for the nucleoside phosphonate analogs adefovir, cidofovir, and tenofovir seemed to be decreased in the R50H-hOAT1 variant compared with the wild type, whereas the kinetics of K525I-hOAT1 remained unchanged. Tenofovir 88-97 solute carrier family 22 member 6 Homo sapiens 133-138 15914676-8 2005 Interestingly, the K(m) for the nucleoside phosphonate analogs adefovir, cidofovir, and tenofovir seemed to be decreased in the R50H-hOAT1 variant compared with the wild type, whereas the kinetics of K525I-hOAT1 remained unchanged. Tenofovir 88-97 solute carrier family 22 member 6 Homo sapiens 206-211