PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22889300-8 2012 Virological studies showed that the combination of R284K with TAM1 mutations confers a fitness advantage in the presence of zidovudine or tenofovir. Tenofovir 138-147 stromal interaction molecule 1 Homo sapiens 62-66 22889300-12 2012 CONCLUSIONS: Our study shows the association of R284K and TAM1 mutations in individuals failing therapy with tenofovir/emtricitabine, and unveils a novel mechanism by which secondary mutations are selected in the context of drug-resistance mutations. Tenofovir 109-118 stromal interaction molecule 1 Homo sapiens 58-62