PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29641561-7	2018	Further, four of the six AK2 variants predicted to result in a loss or decrease of enzyme function exhibited a >=30% decrease in activity towards tenofovir in our in vitro assays.	Tenofovir	149-158	adenylate kinase 2	Homo sapiens	25-28	
25091927-4	2014	The phosphonate was shown to be a moderate but selective substrate of the mitochondrial human AK2, better than well-known antiviral acyclic phosphonates 9-(2-phosphonomethoxyethyl)adenine (PMEA, Adefovir) and (R)-9-(2-phosphonomethoxypropyl)adenine (PMPA, Tenofovir).	Tenofovir	209-248	adenylate kinase 2	Homo sapiens	94-97	
25091927-4	2014	The phosphonate was shown to be a moderate but selective substrate of the mitochondrial human AK2, better than well-known antiviral acyclic phosphonates 9-(2-phosphonomethoxyethyl)adenine (PMEA, Adefovir) and (R)-9-(2-phosphonomethoxypropyl)adenine (PMPA, Tenofovir).	Tenofovir	250-254	adenylate kinase 2	Homo sapiens	94-97	
25091927-4	2014	The phosphonate was shown to be a moderate but selective substrate of the mitochondrial human AK2, better than well-known antiviral acyclic phosphonates 9-(2-phosphonomethoxyethyl)adenine (PMEA, Adefovir) and (R)-9-(2-phosphonomethoxypropyl)adenine (PMPA, Tenofovir).	Tenofovir	256-265	adenylate kinase 2	Homo sapiens	94-97	
29641561-2	2018	Adenylate kinase 2 (AK2) has been previously demonstrated to phosphorylate tenofovir to tenofovir-monophosphate, while creatine kinase, muscle (CKM), pyruvate kinase, muscle (PKM) and pyruvate kinase, liver and red blood cell (PKLR) each have been found to phosphorylate tenofovir-monophosphate to the pharmacologically active tenofovir-diphosphate.	Tenofovir	75-84	adenylate kinase 2	Homo sapiens	0-18	
29641561-2	2018	Adenylate kinase 2 (AK2) has been previously demonstrated to phosphorylate tenofovir to tenofovir-monophosphate, while creatine kinase, muscle (CKM), pyruvate kinase, muscle (PKM) and pyruvate kinase, liver and red blood cell (PKLR) each have been found to phosphorylate tenofovir-monophosphate to the pharmacologically active tenofovir-diphosphate.	Tenofovir	75-84	adenylate kinase 2	Homo sapiens	20-23	
29641561-5	2018	To functionally test these predictions, AK2 and AK2 variants were expressed in and purified from E. coli, followed by investigation of their activities towards tenofovir.	Tenofovir	160-169	adenylate kinase 2	Homo sapiens	40-43	
29641561-5	2018	To functionally test these predictions, AK2 and AK2 variants were expressed in and purified from E. coli, followed by investigation of their activities towards tenofovir.	Tenofovir	160-169	adenylate kinase 2	Homo sapiens	48-51	
29641561-6	2018	Interestingly, we found that purified AK2 had the ability to phosphorylate tenofovir-monophosphate to tenofovir-diphosphate in addition to phosphorylating tenofovir to tenofovir-monophosphate.	Tenofovir	75-84	adenylate kinase 2	Homo sapiens	38-41	
29455571-4	2018	We previously demonstrated that adenylate kinase 2, pyruvate kinase, muscle and pyruvate kinase, liver and red blood cell phosphorylate TFV in peripheral blood mononuclear cells (PBMC).	Tenofovir	136-139	adenylate kinase 2	Homo sapiens	32-50