PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23970434-0 2013 Effects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humans. montelukast 84-95 solute carrier organic anion transporter family member 2B1 Homo sapiens 32-39 26694455-1 2015 Clinical studies with montelukast show variability in effect and polymorphic OATP2B1-dependent absorption has previously been implicated as a possible cause. montelukast 22-33 solute carrier organic anion transporter family member 2B1 Homo sapiens 77-84 26694455-4 2015 Montelukast is a carboxylic acid, a relatively potent inhibitor of OATP1B1, OATP1B3, and OATP2B1, and has previously been postulated to be actively transported into human hepatocytes. montelukast 0-11 solute carrier organic anion transporter family member 2B1 Homo sapiens 89-96 23970434-1 2013 Montelukast, a leukotriene receptor antagonist, is a substrate of organic anion transporting OATP2B1 encoded by the SLCO2B1. montelukast 0-11 solute carrier organic anion transporter family member 2B1 Homo sapiens 93-100 23970434-1 2013 Montelukast, a leukotriene receptor antagonist, is a substrate of organic anion transporting OATP2B1 encoded by the SLCO2B1. montelukast 0-11 solute carrier organic anion transporter family member 2B1 Homo sapiens 116-123 20974993-0 2011 Effect of citrus juice and SLCO2B1 genotype on the pharmacokinetics of montelukast. montelukast 71-82 solute carrier organic anion transporter family member 2B1 Homo sapiens 27-34 23151832-1 2013 OBJECTIVE: A nonsynonymous single nucleotide polymorphism (SNP) in the SLCO2B1 gene encoding organic anion transporting polypeptide 2B1 (OATP2B1), c.935G>A (p.R312Q; rs12422149), has been associated with reduced plasma concentrations of montelukast in patients with asthma. montelukast 240-251 solute carrier organic anion transporter family member 2B1 Homo sapiens 71-78 23151832-1 2013 OBJECTIVE: A nonsynonymous single nucleotide polymorphism (SNP) in the SLCO2B1 gene encoding organic anion transporting polypeptide 2B1 (OATP2B1), c.935G>A (p.R312Q; rs12422149), has been associated with reduced plasma concentrations of montelukast in patients with asthma. montelukast 240-251 solute carrier organic anion transporter family member 2B1 Homo sapiens 93-135 23151832-1 2013 OBJECTIVE: A nonsynonymous single nucleotide polymorphism (SNP) in the SLCO2B1 gene encoding organic anion transporting polypeptide 2B1 (OATP2B1), c.935G>A (p.R312Q; rs12422149), has been associated with reduced plasma concentrations of montelukast in patients with asthma. montelukast 240-251 solute carrier organic anion transporter family member 2B1 Homo sapiens 137-144 23151832-2 2013 Our aim was to examine the possible effects of the SLCO2B1 c.935G>A SNP on the single-dose pharmacokinetics of the suggested OATP2B1 substrates montelukast and aliskiren. montelukast 147-158 solute carrier organic anion transporter family member 2B1 Homo sapiens 51-58 23151832-2 2013 Our aim was to examine the possible effects of the SLCO2B1 c.935G>A SNP on the single-dose pharmacokinetics of the suggested OATP2B1 substrates montelukast and aliskiren. montelukast 147-158 solute carrier organic anion transporter family member 2B1 Homo sapiens 128-135 20974993-1 2011 Previously the authors found that a common polymorphism, rs12422149 (SLCO2B1{NM_007256.2}:c.935G>A), in the gene coding for OATP2B1, was associated with absorption of and response to montelukast in humans. montelukast 186-197 solute carrier organic anion transporter family member 2B1 Homo sapiens 69-76 20974993-1 2011 Previously the authors found that a common polymorphism, rs12422149 (SLCO2B1{NM_007256.2}:c.935G>A), in the gene coding for OATP2B1, was associated with absorption of and response to montelukast in humans. montelukast 186-197 solute carrier organic anion transporter family member 2B1 Homo sapiens 127-134 19151602-7 2009 An MDCKII cell line expressing OATP2B1 (coded for by the SLCO2B1 gene) displays significantly increased permeability of montelukast (P<0.05, percentage of control: 140+/-20). montelukast 120-131 solute carrier organic anion transporter family member 2B1 Homo sapiens 31-38 19151602-9 2009 CONCLUSION: Altogether, these observations suggest that the genetics of SLCO2B1 may be an important variable in determining the pharmacokinetics and the pharmacodynamics of montelukast. montelukast 173-184 solute carrier organic anion transporter family member 2B1 Homo sapiens 72-79