PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33588236-3	2021	Here, we show that phosphodiesterase-5 inhibitors, sildenafil and tadalafil, promote IFN-gamma and IL-4 production in iNKT cells in a cGMP-PKG pathway dependent manner.	Tadalafil	66-75	protein kinase cGMP-dependent 1	Homo sapiens	139-142	
31654676-8	2020	Intriguingly, we found that the oocyte maturation could be stimulated by treatment of either two different PDE5a inhibitors, sildenafil or tadalafil, and such effects could be completely blocked by a PKG inhibitor KT5823 and two gap junction blockers, respectively.	Tadalafil	139-148	protein kinase cGMP-dependent 1	Homo sapiens	200-203	
26551887-7	2016	The apoptotic effects of the sGC activator BAY 41-2272 and the PDE5 inhibitor Tadalafil (Cialis) were mediated by PKG.	Tadalafil	78-87	protein kinase cGMP-dependent 1	Homo sapiens	114-117	
26551887-7	2016	The apoptotic effects of the sGC activator BAY 41-2272 and the PDE5 inhibitor Tadalafil (Cialis) were mediated by PKG.	Tadalafil	89-95	protein kinase cGMP-dependent 1	Homo sapiens	114-117	
23765639-8	2013	RESULTS: In vitro treatment with tadalafil or vardenafil on hBPH reduced IL-8 secretion induced by either TNFalpha or metabolic factors, including oxidized low-density lipoprotein, oxLDL, to the same extent as a PDE5-insensitive PKG agonist Sp-8-Br-PET-cGMP.	Tadalafil	33-42	protein kinase cGMP-dependent 1	Homo sapiens	229-232	
20543097-12	2010	Moreover, the tadalafil-treated group demonstrated increased cardiac cGMP level and protein kinase G (PKG) activity.	Tadalafil	14-23	protein kinase cGMP-dependent 1	Homo sapiens	84-100	
20543097-12	2010	Moreover, the tadalafil-treated group demonstrated increased cardiac cGMP level and protein kinase G (PKG) activity.	Tadalafil	14-23	protein kinase cGMP-dependent 1	Homo sapiens	102-105	
20543097-14	2010	We conclude that tadalafil improved left ventricular function and prevented cardiomyocyte apoptosis in DOX-induced cardiomyopathy through mechanisms involving up-regulation of cGMP, PKG activity, and MnSOD level without interfering with the chemotherapeutic benefits of DOX.	Tadalafil	17-26	protein kinase cGMP-dependent 1	Homo sapiens	182-185