PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33718236-0 2021 Overexpression of ABCC1 Confers Drug Resistance to Betulin. betulin 51-58 ATP binding cassette subfamily C member 1 Homo sapiens 18-23 33718236-3 2021 Herein, we explored the factors that may result in betulin resistance, especially with respect to its interaction with ATP-binding cassette subfamily C member 1 (ABCC1). betulin 51-58 ATP binding cassette subfamily C member 1 Homo sapiens 119-160 33718236-3 2021 Herein, we explored the factors that may result in betulin resistance, especially with respect to its interaction with ATP-binding cassette subfamily C member 1 (ABCC1). betulin 51-58 ATP binding cassette subfamily C member 1 Homo sapiens 162-167 33718236-5 2021 An MTT-based cell viability assay showed that ABCC1 overexpression has the ability to desensitize both cancer cell line and gene-transfected cell line to betulin and that this betulin-induced resistance can be antagonized by a known ABCC1 inhibitor MK571 at 25 muM. betulin 154-161 ATP binding cassette subfamily C member 1 Homo sapiens 46-51 33718236-5 2021 An MTT-based cell viability assay showed that ABCC1 overexpression has the ability to desensitize both cancer cell line and gene-transfected cell line to betulin and that this betulin-induced resistance can be antagonized by a known ABCC1 inhibitor MK571 at 25 muM. betulin 176-183 ATP binding cassette subfamily C member 1 Homo sapiens 46-51 33718236-5 2021 An MTT-based cell viability assay showed that ABCC1 overexpression has the ability to desensitize both cancer cell line and gene-transfected cell line to betulin and that this betulin-induced resistance can be antagonized by a known ABCC1 inhibitor MK571 at 25 muM. betulin 176-183 ATP binding cassette subfamily C member 1 Homo sapiens 233-238 33718236-6 2021 Additionally, betulin upregulates the ABCC1 protein expression level in both concentration-dependent and time-dependent manners, also blocks the transport function mediated by ABCC1. betulin 14-21 ATP binding cassette subfamily C member 1 Homo sapiens 38-43 33718236-6 2021 Additionally, betulin upregulates the ABCC1 protein expression level in both concentration-dependent and time-dependent manners, also blocks the transport function mediated by ABCC1. betulin 14-21 ATP binding cassette subfamily C member 1 Homo sapiens 176-181 33718236-7 2021 Subsequently, a high affinity score of betulin was achieved in a computational docking analysis, demonstrating a strong interaction of betulin with ABCC1. betulin 39-46 ATP binding cassette subfamily C member 1 Homo sapiens 148-153 33718236-7 2021 Subsequently, a high affinity score of betulin was achieved in a computational docking analysis, demonstrating a strong interaction of betulin with ABCC1. betulin 135-142 ATP binding cassette subfamily C member 1 Homo sapiens 148-153