PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31274831-12 2020 In HPDE cells subjected to oxidative stress olaparib (1 muM) inhibited PARP activity, protected against the loss of cell viability and prevented the loss of cellular NAD levels. olaparib 44-52 latexin Homo sapiens 56-59 22524618-8 2012 RESULTS: A radiosensitizing effect of olaparib was seen even at 0.01 muM. olaparib 38-46 latexin Homo sapiens 69-72 22524618-12 2012 This sensitizing effect was seen at low concentrations of olaparib such as 0.01 muM, and its sensitizing effect was the same at both 0.01 muM and 1 muM. olaparib 58-66 latexin Homo sapiens 80-83 31071432-17 2019 In in vitro experiments in U937 cells subjected to oxidative stress, olaparib (1-100 muM) inhibited PARP activity, protected against the loss of cell viability, preserved NAD+ levels and improved cellular bioenergetics. olaparib 69-77 latexin Homo sapiens 85-88 29064327-8 2017 In vitro assay, the half maximal inhibitory concentration of olaparib in HCC1937-APE1-KO was significantly increased (17.22 vs 91.85 muM) compared to the wild type. olaparib 61-69 latexin Homo sapiens 133-136 29064327-10 2017 HCC1937 resulted in more mitotic G2/M arrest and increased apoptosis rate after treatment with 40 muM of olaparib, while HCC1937-APE1-KO did not change significantly. olaparib 105-113 latexin Homo sapiens 98-101 29064327-11 2017 When HCC1937 was treated with different concentrations of olaparib, it was found that APE1 expression decreased more significantly at 15 muM of olaparib was. olaparib 58-66 latexin Homo sapiens 137-140 29064327-11 2017 When HCC1937 was treated with different concentrations of olaparib, it was found that APE1 expression decreased more significantly at 15 muM of olaparib was. olaparib 144-152 latexin Homo sapiens 137-140 28657402-8 2018 In a further study, olaparib (2-200 muM) functioned as a time-dependent inhibitor of CYP3A4/5 (KI, 72.2 muM and Kinact, 0.0675 min-1). olaparib 20-28 latexin Homo sapiens 36-39 28657402-8 2018 In a further study, olaparib (2-200 muM) functioned as a time-dependent inhibitor of CYP3A4/5 (KI, 72.2 muM and Kinact, 0.0675 min-1). olaparib 20-28 latexin Homo sapiens 104-107 28657402-9 2018 Assessment of the CYP induction potential of olaparib (0.061-44 muM) showed minor concentration-related increases in CYP1A2 and more marked increases in CYP2B6 and CYP3A4 mRNA, compared with positive control activity; however, no significant change in CYP3A4/5 enzyme activity was observed. olaparib 45-53 latexin Homo sapiens 64-67