PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34761497-6 2021 Further analysis of the underlying molecular mechanism underlying the MET suppression-induced drug sensitivity revealed that olaparib and crizotinib could together downregulate the ATM/ATR signaling pathway, inducing apoptosis by inhibiting the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway, enhancing the olaparib-induced antitumour effect in DU145 and PC3 cells. olaparib 125-133 AKT serine/threonine kinase 1 Homo sapiens 294-297 27055253-5 2016 Using reverse-phase protein array, we found the proteins most significantly upregulated following treatment with the PARP inhibitors olaparib and rucaparib were in the PI3K/mTOR pathway (p-mTOR, p-AKT, and pS6) (p<=0.02). olaparib 133-141 AKT serine/threonine kinase 1 Homo sapiens 197-200 26124328-3 2015 BEZ235 reduced olaparib-induced phosphorylation of p53 binding protein 1 (53BP1) and 53BP1 foci formation, as well as phosphorylation of AKT (S473). olaparib 15-23 AKT serine/threonine kinase 1 Homo sapiens 137-140 33669671-2 2021 In this study we examined the different responses of triple-negative breast cancer line MDA-MB-231 and hormone receptor-positive breast cancer line MCF7 to a combined treatment including olaparib, a poly-(ADP ribose) polymerase (PARP) inhibitor, oxaliplatin, a third-generation platinum compound and LY294002, an Akt pathway inhibitor. olaparib 187-195 AKT serine/threonine kinase 1 Homo sapiens 313-316 35419627-9 2022 Inhibition of AKT further increased the response of tumor cells to Olaparib in a PDX model derived from a recurrent platinum-resistant ovarian cancer patient. olaparib 67-75 AKT serine/threonine kinase 1 Homo sapiens 14-17 35419627-11 2022 Interestingly, mechanism study revealed that AKT inhibition decreased PARP enzyme activity as measured by PAR level and/or reduced PARP1 protein level in the tumor cell lines and PDX tumor tissues, which may explain the observed combined anti-tumor effect of LAE003 and Olaparib. olaparib 270-278 AKT serine/threonine kinase 1 Homo sapiens 45-48 32388810-7 2020 In addition, TRAF4"s effect on the sensitivity of EC cells to olaparib was further found to be mainly mediated by Akt phosphorylation. olaparib 62-70 AKT serine/threonine kinase 1 Homo sapiens 114-117 33093458-11 2020 Finally, our results suggested that olaparib inhibited the PI3K/AKT pathway in STAD cells, and up-regulation of ClC-3/SGK1 axis enhanced olaparib-induced PI3K/AKT pathway inhibition. olaparib 137-145 AKT serine/threonine kinase 1 Homo sapiens 159-162 27465688-9 2016 MK-2206 prevented cisplatin- and olaparib-induced AKT activation in the BRCA2-deficient PEO1 cells. olaparib 33-41 AKT serine/threonine kinase 1 Homo sapiens 50-53 31714594-11 2020 Treatment with olaparib increased phosphorylation of ATM and PTEN while decreasing the phosphorylation of AKT and mTOR and inducing autophagy. olaparib 15-23 AKT serine/threonine kinase 1 Homo sapiens 106-109 31438892-5 2019 Expression and phosphorylation of NF-kB, EGFR, Akt, p38, ERK was also observed in A549 and H1299 cells exposed with 12C ion with and without PARP-1 inhibition using siRNA or olaparib. olaparib 174-182 AKT serine/threonine kinase 1 Homo sapiens 47-50 30357520-8 2019 Downregulation of phospho-AKT levels and accumulation of gammaH2AX, a specific marker of DNA damage, were significantly and persistently induced by Olaparib and AZD2461 exposure, this leading to apoptosis-related cell death. olaparib 148-156 AKT serine/threonine kinase 1 Homo sapiens 26-29 27465688-11 2016 Higher AKT activity is also required to withstand cytotoxic agent-induced DNA damage, leading to strong synergism between MK-2206 and cisplatin or olaparib therapy in BRCA-deficient cells. olaparib 147-155 AKT serine/threonine kinase 1 Homo sapiens 7-10