PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28657402-9 2018 Assessment of the CYP induction potential of olaparib (0.061-44 muM) showed minor concentration-related increases in CYP1A2 and more marked increases in CYP2B6 and CYP3A4 mRNA, compared with positive control activity; however, no significant change in CYP3A4/5 enzyme activity was observed. olaparib 45-53 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 153-159 28657402-12 2018 It is recommended that olaparib is given with caution with narrow therapeutic range or sensitive CYP3A substrates, and that prescribers are aware that olaparib may reduce exposure to substrates of CYP2B6. olaparib 151-159 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 197-203