PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34115723-7 2021 The benefit of olaparib and other clinically approved PARP inhibitors has already been demonstrated in several experimental models of human diseases, such as neurodegeneration and neuroinflammation, acute hepatitis, skeletal muscle disorders, aging and acute ischemic stroke, protecting, for example, from the deterioration of the blood-brain barrier, restoring the cellular levels of NAD+, improving mitochondrial function and biogenesis and, among other effects, reducing oxidative stress and pro-inflammatory mediators, such as TNF-alpha, IL1-beta, IL-6 and VCAM1. olaparib 15-23 interleukin 1 alpha Homo sapiens 542-550 34567413-7 2021 Olaparib reduced the inflammation score, the concentration of IL-1beta and IL-6, enhanced the level of IL-10, and decreased the intestinal permeability in TNBS-colitis. olaparib 0-8 interleukin 1 alpha Homo sapiens 62-70