PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35406579-5 2022 RESULTS: In ID8, cells with a HR proficient background, olaparib resistance was mainly caused by overexpression of multidrug resistance 1 gene (MDR1), while multiple heterogeneous co-existing mechanisms were found in ID8 Brca1-/- HR-deficient cells resistant to olaparib, including overexpression of MDR1, a decrease in PARP1 protein level and partial reactivation of HR repair. olaparib 56-64 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 144-148 35406579-5 2022 RESULTS: In ID8, cells with a HR proficient background, olaparib resistance was mainly caused by overexpression of multidrug resistance 1 gene (MDR1), while multiple heterogeneous co-existing mechanisms were found in ID8 Brca1-/- HR-deficient cells resistant to olaparib, including overexpression of MDR1, a decrease in PARP1 protein level and partial reactivation of HR repair. olaparib 56-64 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 300-304 35406579-5 2022 RESULTS: In ID8, cells with a HR proficient background, olaparib resistance was mainly caused by overexpression of multidrug resistance 1 gene (MDR1), while multiple heterogeneous co-existing mechanisms were found in ID8 Brca1-/- HR-deficient cells resistant to olaparib, including overexpression of MDR1, a decrease in PARP1 protein level and partial reactivation of HR repair. olaparib 262-270 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 144-148