PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33949005-2	2021	Loss of CBS activity due to mutation results in CBS deficiency, an inborn error of metabolism characterized by extreme elevation of plasma total homocysteine (tHcy).	thcy	159-163	cystathionine beta-synthase	Mus musculus	8-11	
34528713-1	2021	Cystathionine beta-synthase (CBS) deficiency is a recessive inborn error of sulfur metabolism characterized by elevated blood levels of total homocysteine (tHcy).	thcy	156-160	cystathionine beta-synthase	Mus musculus	0-27	
31240737-5	2019	Zinc-treated Tg-R336C Cbs -/- mice have extreme elevation in both serum total homocysteine (tHcy) and liver tHcy compared with control transgenic mice.	thcy	92-96	cystathionine beta-synthase	Mus musculus	22-25	
31084364-1	2019	Cystathionine beta-synthase (CBS) deficiency is a recessive inborn error of metabolism characterized by extremely elevated total homocysteine (tHcy) in the blood.	thcy	143-147	cystathionine beta-synthase	Mus musculus	0-27	
31240737-5	2019	Zinc-treated Tg-R336C Cbs -/- mice have extreme elevation in both serum total homocysteine (tHcy) and liver tHcy compared with control transgenic mice.	thcy	108-112	cystathionine beta-synthase	Mus musculus	22-25	
27183385-5	2016	Here, we have shown that administration of PEGylated CBS into the circulation of homocystinuria model mice alters the extra- and intracellular equilibrium of sulfur amino acids, resulting in a decrease of approximately 75% in plasma total homocysteine (tHcy) and normalization of cysteine concentrations.	thcy	253-257	cystathionine beta-synthase	Mus musculus	53-56	
24189943-4	2014	Cbs(-/-) mice fed the MRD had a 77% decrease in tHcy, 28% increase in weight, 130% increase in fat mass, 82% increase in Scd-1 expression, and 10.6% increase in bone density and entirely lacked the alopecia phenotype observed in age-matched Cbs(-/-) mice fed the RD.	thcy	48-52	cystathionine beta-synthase	Mus musculus	0-3	
26599618-2	2016	Mutations in the CBS gene cause clinical CBS deficiency, a disease characterized by elevated plasma total homocysteine (tHcy) and methionine and decreased plasma cysteine.	thcy	120-124	cystathionine beta-synthase	Mus musculus	17-20	
26599618-5	2016	Tg-I278T Cbs(-/-) mice have undetectable levels of CBS activity, extremely elevated plasma tHcy, modestly elevated plasma methionine, and low plasma cysteine.	thcy	91-95	cystathionine beta-synthase	Mus musculus	9-12	
26231230-1	2016	Cystathionine beta synthase (CBS) deficiency is a recessive inborn error of metabolism characterized by elevated serum total homocysteine (tHcy).	thcy	139-143	cystathionine beta-synthase	Mus musculus	0-27	
26231230-5	2016	Tg-I278T Cbs (-/-) mice on betaine, from the time of weaning until for 240 days of age, had a 40 % decrease in mean tHcy level and a 137 % increase in serum methionine levels.	thcy	116-120	cystathionine beta-synthase	Mus musculus	9-12	
20036517-5	2010	Because CBS is a key regulator of tHcy, we examined CBS protein levels and found that within 3 d on the methionine-deficient diet, animals had a 50% reduction in the levels of liver CBS protein and enzyme activity.	thcy	34-38	cystathionine beta-synthase	Mus musculus	8-11	
17537983-5	2007	The higher renal CBS activity in males (22.7 +/- 3.1 mmol cystathionine.h(-1).kg kidney(-1)) vs. females (8.4 +/- 3.4 mmol cystathionine.h(-1).kg kidney(-1), P < or = 10(-6)) in C57Bl/6J mice was associated with lower plasma tHcy levels in males vs. females, and this difference was exacerbated in Cbs+/- mice (7.7 +/- 1.9 micromol/l in males vs. 13.8 +/- 6.4 micromol/l in females, P = 0.005).	thcy	228-232	cystathionine beta-synthase	Mus musculus	17-20	
17537983-4	2007	Renal function is known to be an important determinant of tHcy, and, in this study, we demonstrate that renal CBS expression and activity in mice diminished approximately twofold after castration, whereas ovariectomization was without effect.	thcy	58-62	cystathionine beta-synthase	Mus musculus	110-113