PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35208888-0 2022 Ten-Week Sucralose Consumption Induces Gut Dysbiosis and Altered Glucose and Insulin Levels in Healthy Young Adults. trichlorosucrose 9-18 insulin Homo sapiens 77-84 11679438-1 2001 In patients with type 2 diabetes, a strong correlation between accumulation of intramuscular triclycerides (TGs) and insulin resistance has been found. trichlorosucrose 108-111 insulin Homo sapiens 117-124 34581796-15 2021 Sucrose vs sucralose was associated with greater production of circulating glucose, insulin, and glucagon-like peptide-1 and suppression of acyl-ghrelin, but no differences were found for peptide YY or leptin. trichlorosucrose 11-20 insulin Homo sapiens 84-91 35208888-8 2022 Sucralose consumption increased serum insulin and the area under the glucose curve compared to water. trichlorosucrose 0-9 insulin Homo sapiens 38-45 35208888-9 2022 Long-term sucralose ingestion induces gut dysbiosis associated with altered insulin and glucose levels during an OGTT. trichlorosucrose 10-19 insulin Homo sapiens 76-83 31877631-5 2019 In contrast, the insulin response to sucralose ingestion differed depending on the presence of obesity: decreased within 20-40 min of the OGTT in normal-weight participants but increased within 90-120 min in participants with obesity. trichlorosucrose 37-46 insulin Homo sapiens 17-24 32711853-3 2020 OBJECTIVE: The aim of this study was to evaluate whether sucralose consumption could produce changes in fasting plasma concentrations of appetite-regulating hormones, including glucagon-like peptide 1, ghrelin, peptide tyrosine tyrosine, and leptin, and secondarily in insulin resistance. trichlorosucrose 57-66 insulin Homo sapiens 269-276 33535094-3 2021 shows that the impairment of insulin sensitivity by sucralose in combination with carbohydrate may be explained by the carbohydrate component rather than the low-calorie sweetener. trichlorosucrose 52-61 insulin Homo sapiens 29-36 31877631-6 2019 Sham-fed sucralose similarly decreased insulin concentrations within 60 min of the OGTT in both weight groups. trichlorosucrose 9-18 insulin Homo sapiens 39-46 31183389-0 2019 A Single 48 mg Sucralose Sip Unbalances Monocyte Subpopulations and Stimulates Insulin Secretion in Healthy Young Adults. trichlorosucrose 15-24 insulin Homo sapiens 79-86 31183389-12 2019 This work demonstrates for the first time that a 48 mg sucralose sip increases serum insulin and unbalances monocyte subpopulations expressing CD11c and CD206 in noninsulin-resistant healthy young adults subjected to an OGTT. trichlorosucrose 55-64 insulin Homo sapiens 85-92 31183389-3 2019 Our goal was to examine the effect of a single sucralose sip on serum insulin and blood glucose and the percentages of classical, intermediate, and nonclassical monocytes in healthy young adults subjected to an oral glucose tolerance test (OGTT). trichlorosucrose 47-56 insulin Homo sapiens 70-77 31183389-8 2019 As compared to controls, volunteers receiving sucralose exhibited significant increases in serum insulin at 30, 45, and 180 minutes, whereas blood glucose values showed no significant differences. trichlorosucrose 46-55 insulin Homo sapiens 97-104 31183389-10 2019 Pearson"s correlation models revealed a strong association of insulin with sucralose-induced monocyte subpopulation unbalance whereas glucose values did not show significant correlations. trichlorosucrose 75-84 insulin Homo sapiens 62-69 30005329-9 2018 Whole-body insulin sensitivity (estimated using the Matsuda index) was lower in sucralose than placebo (4.69 +- 1.67 versus 5.31 +- 2.56, P < 0.005). trichlorosucrose 80-89 insulin Homo sapiens 11-18 30005329-11 2018 CONCLUSIONS: The continuous exposure to sucralose reduced AIR, decreased insulin sensitivity, and enhanced GLP-1 release in healthy subjects. trichlorosucrose 40-49 insulin Homo sapiens 73-80 30535090-7 2018 Results: Individuals assigned to sucralose consumption showed a significant decrease in insulin sensitivity with a median (IQR) percentage change of -17.7% (-29.3% to -1.0%) in comparison to -2.8% (-30.7% to 40.6%) in the control group (P= 0.04). trichlorosucrose 33-42 insulin Homo sapiens 88-95 30535090-8 2018 An increased acute insulin response to glucose from 577 mU L-1 min (350-1040 mU L-1 min) to 671 mU L-1 min (376-1010 mU L-1 min) (P = 0.04) was observed in the sucralose group for participants with adequate adherence. trichlorosucrose 172-181 insulin Homo sapiens 19-26 24639763-8 2013 CONCLUSION: Due to positive correlation of hypertriglyceridemia and hyperinsulinemia with newborn weight, it is possible to assume that elevated TGs levels in GDM cases is a reflection of variation in maternal insulin levels. trichlorosucrose 145-148 insulin Homo sapiens 73-80 28899680-8 2017 Among responders exposed to the same sweetener in Phases 1 and 3, the proportion of participants that displayed a rise of insulin with oral exposure to sucralose was significantly greater when the stimulus was in the solid form compared to the beverage form. trichlorosucrose 152-161 insulin Homo sapiens 122-129 28899680-9 2017 Sucralose and sucrose exposure elicited similarly significant increases in serum insulin 2min after exposure and significant decreases after 2min in responders in both food forms. trichlorosucrose 0-9 insulin Homo sapiens 81-88 25271009-8 2015 Total AUC of insulin and c-peptide was similar in aspartame, sucralose and water settings. trichlorosucrose 61-70 insulin Homo sapiens 13-20 23633524-8 2013 CONCLUSIONS: These data demonstrate that sucralose affects the glycemic and insulin responses to an oral glucose load in obese people who do not normally consume NNS. trichlorosucrose 41-50 insulin Homo sapiens 76-83 27099245-3 2016 OBJECTIVE: We determined the effects of sucrose, fructose, and sucralose on triglyceride, glucose, and insulin in an acute study in healthy, overweight, and obese individuals. trichlorosucrose 63-72 insulin Homo sapiens 103-110 24219506-11 2013 Both human and rodent studies demonstrated that sucralose may alter glucose, insulin, and glucagon-like peptide 1 (GLP-1) levels. trichlorosucrose 48-57 insulin Homo sapiens 77-84 24172697-0 2013 Dessert formulation using sucralose and dextrin affects favorably postprandial response to glucose, insulin, and C-peptide in type 2 diabetic patients. trichlorosucrose 26-35 insulin Homo sapiens 113-122