PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33129919-5	2021	The T12 peptide-modified albumin nanoparticles coloaded with regorafenib and disulfiram/copper ion chelate repolarized the tumor-promoting CD206hi TGF-beta1+ MPhi via inhibition of FROUNT and thus remodeled tumor immune microenvironment.	regorafenib	61-72	transforming growth factor beta 1	Homo sapiens	147-156	
33671452-0	2021	Regorafenib-Attenuated, Bleomycin-Induced Pulmonary Fibrosis by Inhibiting the TGF-beta1 Signaling Pathway.	regorafenib	0-11	transforming growth factor beta 1	Homo sapiens	79-88	
33671452-6	2021	Further in vitro mechanism studies showed that regorafenib inhibits the activation and migration of myofibroblasts and extracellular matrix production, mainly through suppressing the transforming growth factor (TGF)-beta1/Smad and non-Smad signaling pathways.	regorafenib	47-58	transforming growth factor beta 1	Homo sapiens	183-221	
33671452-7	2021	In vitro studies have also indicated that regorafenib could augment autophagy in myofibroblasts by suppressing TGF-beta1/mTOR (mechanistic target of rapamycin) signaling, and could promote apoptosis in myofibroblasts.	regorafenib	42-53	transforming growth factor beta 1	Homo sapiens	111-120	
33671452-8	2021	In conclusion, regorafenib attenuates bleomycin-induced pulmonary fibrosis by suppressing the TGF-beta1 signaling pathway.	regorafenib	15-26	transforming growth factor beta 1	Homo sapiens	94-103	
27580057-6	2016	Notably, regorafenib exerted potent anti-EMT activity to curb TGF-beta1-induced EMT/invasion in vitro as well inhibited lung metastatic outgrowth of SW480 mesenchymal cells in vivo.	regorafenib	9-20	transforming growth factor beta 1	Homo sapiens	62-71	
27580057-7	2016	Mechanistically, regorafenib-enhanced SHP-1 activity significantly impeded TGF-beta1-induced EMT/invasion via low p-STAT3Tyr705 level as proved by a SHP-1 inhibitor or siRNA-mediated SHP-1 depletion.	regorafenib	17-28	transforming growth factor beta 1	Homo sapiens	75-84	
27580057-8	2016	Conversely, overexpression of SHP-1 further enhanced the inhibitory effects of regorafenib on TGF-beta1-induced p-STAT3Tyr705 and EMT/invasion.	regorafenib	79-90	transforming growth factor beta 1	Homo sapiens	94-103	
27580057-9	2016	Regorafenib directly activates SHP-1 by potently relieving the autoinhibited N-SH2 domain of SHP-1 to inhibit TGF-beta1-induced p-STAT3Tyr705 and EMT/invasion.	regorafenib	0-11	transforming growth factor beta 1	Homo sapiens	110-119	
34525385-6	2021	Mechanistically, inhibition of VEGFR suppresses TGFB1 expression via the MEK pathway and TGFB1 downregulation directly mediates the effect of regorafenib on hair cell reprogramming.	regorafenib	142-153	transforming growth factor beta 1	Homo sapiens	89-94