PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25473295-1	2014	Here we report a case of metastatic colon cancer treated with 5-fluorouracil, leucovorin, and escalated doses of irinotecan (FOLFIRI) combined with regorafenib in the fourth-line setting after uridine diphosphate glucuronosyltransferase (UGT)1A1 genotyping analysis.	regorafenib	148-159	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	238-245	
31445021-1	2019	We have demonstrated previously that the kinase inhibitors (KIs) lapatinib, pazopanib, regorafenib and sorafenib are potent inhibitors of UGT1A1 and UGTs 1A7-1A10.	regorafenib	87-98	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	138-144	
27938508-0	2017	Regorafenib Plus FOLFIRI With Irinotecan Dose Escalated According to Uridine Diphosphate Glucuronosyltransferase 1A1 Genotyping in Patients With Metastatic Colorectal Cancer.	regorafenib	0-11	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	69-116	
27938508-8	2017	Our findings indicate that regorafenib plus FOLFIRI with irinotecan dose escalation based on UGT1A1 genotyping in previously treated patients with mCRC and with UGT1A1*1/*1 and UGT1A1*1/*28 genotypes is clinically effective and yields improved oncological outcomes.	regorafenib	27-38	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	93-99	
27938508-8	2017	Our findings indicate that regorafenib plus FOLFIRI with irinotecan dose escalation based on UGT1A1 genotyping in previously treated patients with mCRC and with UGT1A1*1/*1 and UGT1A1*1/*28 genotypes is clinically effective and yields improved oncological outcomes.	regorafenib	27-38	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	161-167	
27938508-8	2017	Our findings indicate that regorafenib plus FOLFIRI with irinotecan dose escalation based on UGT1A1 genotyping in previously treated patients with mCRC and with UGT1A1*1/*1 and UGT1A1*1/*28 genotypes is clinically effective and yields improved oncological outcomes.	regorafenib	27-38	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	161-167