PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29573334-0 2018 FGFR2 amplification is predictive of sensitivity to regorafenib in gastric and colorectal cancers in vitro. regorafenib 52-63 fibroblast growth factor receptor 2 Homo sapiens 0-5 29573334-3 2018 Mutation profiles and copy number assays of regorafenib target molecules indicated that amplification of fibroblast growth factor receptor 2 (FGFR2) was the only genetic alteration associated with in vitro sensitivity to regorafenib. regorafenib 221-232 fibroblast growth factor receptor 2 Homo sapiens 105-140 29573334-3 2018 Mutation profiles and copy number assays of regorafenib target molecules indicated that amplification of fibroblast growth factor receptor 2 (FGFR2) was the only genetic alteration associated with in vitro sensitivity to regorafenib. regorafenib 221-232 fibroblast growth factor receptor 2 Homo sapiens 142-147 29573334-4 2018 Regorafenib effectively inhibited phosphorylation of FGFR2 and its downstream signaling molecules in a dose-dependent manner and selectively in FGFR2-amplified cells. regorafenib 0-11 fibroblast growth factor receptor 2 Homo sapiens 53-58 29573334-4 2018 Regorafenib effectively inhibited phosphorylation of FGFR2 and its downstream signaling molecules in a dose-dependent manner and selectively in FGFR2-amplified cells. regorafenib 0-11 fibroblast growth factor receptor 2 Homo sapiens 144-149 29573334-7 2018 Regorafenib effectively abrogates activated FGFR2 signaling in FGFR2-amplified gastric and colorectal cancer and, therefore, might be considered for integration into treatment in patients with FGFR2-amplified gastric and colorectal cancers. regorafenib 0-11 fibroblast growth factor receptor 2 Homo sapiens 44-49 29573334-7 2018 Regorafenib effectively abrogates activated FGFR2 signaling in FGFR2-amplified gastric and colorectal cancer and, therefore, might be considered for integration into treatment in patients with FGFR2-amplified gastric and colorectal cancers. regorafenib 0-11 fibroblast growth factor receptor 2 Homo sapiens 63-68 29573334-7 2018 Regorafenib effectively abrogates activated FGFR2 signaling in FGFR2-amplified gastric and colorectal cancer and, therefore, might be considered for integration into treatment in patients with FGFR2-amplified gastric and colorectal cancers. regorafenib 0-11 fibroblast growth factor receptor 2 Homo sapiens 63-68