PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27752061-6 2016 By inhibiting PTP1B activity, regorafenib treatment augmented the stability of PITX1 protein and upregulated the expression of p120RasGAP in CRC. regorafenib 30-41 RAS p21 protein activator 1 Homo sapiens 127-137 27752061-7 2016 Importantly, we found that this PTP1B-dependant PITX1/p120RasGAP axis determines the in vitro anti-CRC effects of regorafenib. regorafenib 114-125 RAS p21 protein activator 1 Homo sapiens 54-64 27752061-10 2016 Regorafenib inhibited CRC survival through reserving PTP1B-dependant PITX1/p120RasGAP downregulation. regorafenib 0-11 RAS p21 protein activator 1 Homo sapiens 75-85