PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30392788-0	2019	Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer.	regorafenib	0-11	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	24-28	
30392788-2	2019	In this study, we evaluated the effect of regorafenib, an oral multi-kinase inhibitor, in inhibiting BCRP-mediated MDR in silico, in vitro and in vivo.	regorafenib	42-53	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	101-105	
30392788-3	2019	We found that regorafenib significantly sensitized MDR colon cancer cells to BCRP substrates by increasing their intracellular accumulation.	regorafenib	14-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	77-81	
30392788-5	2019	Investigation of the mechanism revealed that regorafenib stimulated BCRP ATPase activity.	regorafenib	45-56	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	68-72	
30392788-6	2019	Our induced-fit docking and molecular dynamics simulations suggested the existence of a strong and stable interaction between regorafenib and the transmembrane domain of human crystalized BCRP.	regorafenib	126-137	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	188-192	
30368586-4	2019	In addition, we determined the association of regorafenib concentrations with ABCG2 and OATP1B1 polymorphisms, which are regorafenib transporters.	regorafenib	46-57	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	78-83	
28157071-0	2017	Association between ABCG2 and SLCO1B1 polymorphisms and adverse drug reactions to regorafenib: a preliminary study : .	regorafenib	82-93	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	20-25	
25563977-5	2015	RESULTS: Regorafenib was transported well by mAbcg2 and hABCG2 and modestly by hABCB1 in vitro.	regorafenib	9-20	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	56-62