PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34992539-3	2021	It has been reported that lacosamide"s effect on NaV1.5 is sensitive to a mutation in the local anesthetic binding site, and that it binds with slow kinetics to the fast-inactivated state of NaV1.7.	Lacosamide	26-36	sodium voltage-gated channel alpha subunit 5	Homo sapiens	49-55	
24563546-11	2014	Unexpectedly, lacosamide elicited a time-dependent block of persistent hNav1.5-CW Na(+) currents with an IC50 of 242 +- 19 microM (n = 5).	Lacosamide	14-24	sodium voltage-gated channel alpha subunit 5	Homo sapiens	71-78	
24563546-12	2014	Furthermore, both hNav1.5-CW/F1760K mutant and batrachotoxin-activated hNav1.5 Na(+) channels became completely lacosamide resistant, indicating that the lacosamide receptor overlaps receptors for local anesthetics and batrachotoxin.	Lacosamide	112-122	sodium voltage-gated channel alpha subunit 5	Homo sapiens	18-25	
24563546-12	2014	Furthermore, both hNav1.5-CW/F1760K mutant and batrachotoxin-activated hNav1.5 Na(+) channels became completely lacosamide resistant, indicating that the lacosamide receptor overlaps receptors for local anesthetics and batrachotoxin.	Lacosamide	112-122	sodium voltage-gated channel alpha subunit 5	Homo sapiens	71-78	
24563546-13	2014	Our results together suggest that lacosamide targets the intermediate preopen and open states of hNav1.5 Na(+) channels.	Lacosamide	34-44	sodium voltage-gated channel alpha subunit 5	Homo sapiens	97-104	
24563546-14	2014	Lacosamide may thus track closely the conformational changes at the hNav1.5-F1760 region along the activation pathway.	Lacosamide	0-10	sodium voltage-gated channel alpha subunit 5	Homo sapiens	68-75