PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26668588-3 2015 Neuronal Nuclei immunohistochemistry demonstrated that pre- and post-surgical treatment (5 min ischemia) with 25 mg/kg lacosamide protected CA1 pyramidal neurons in the lacosamide-treated-ischemia-operated group from ischemic injury 5 days post-ischemia, as compared with gerbils in the vehicle-treated-ischemia-operated group. Lacosamide 119-129 carbonic anhydrase 1 Homo sapiens 140-143 26668588-3 2015 Neuronal Nuclei immunohistochemistry demonstrated that pre- and post-surgical treatment (5 min ischemia) with 25 mg/kg lacosamide protected CA1 pyramidal neurons in the lacosamide-treated-ischemia-operated group from ischemic injury 5 days post-ischemia, as compared with gerbils in the vehicle-treated-ischemia-operated group. Lacosamide 169-179 carbonic anhydrase 1 Homo sapiens 140-143 26668588-4 2015 Furthermore, treatment with 25 mg/kg lacosamide markedly attenuated the activation of astrocytes and microglia in the ischemic CA1 region at 5 days post-ischemia. Lacosamide 37-47 carbonic anhydrase 1 Homo sapiens 127-130 26668588-6 2015 In addition, the neuroprotective effects of lacosamide may be associated with decreased activation of glial cells in the ischemic CA1 region. Lacosamide 44-54 carbonic anhydrase 1 Homo sapiens 130-133