PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32717251-9	2020	However, inhibition of the ER stress response by pretreatment with 4-PBA included apparently and dose-dependently reduced levels of p-PERK, p-IRE1, CHOP, cleaved ATF6, p-ASK1, p-JNK, cleaved caspase-3, procaspase-12, and MMP depolarization in AgNP-treated ARPE-19 cells; it also led to significantly increased Mcl-1 protein levels in a dose-dependent manner in ARPE-19 cells.	4-phenylbutylamine	67-72	DNA damage inducible transcript 3	Homo sapiens	148-152	
34710848-6	2021	In vitro, we used IFNalpha to stimulate human salivary gland epithelial cells (HSGECs), and the results showed that IFNalpha activated GRP78-ATF6-CHOP apoptosis signaling, decreased cell viability, and induced apoptosis, which were negatively regulated by the ERS inhibitor 4-PBA.	4-phenylbutylamine	274-279	DNA damage inducible transcript 3	Homo sapiens	146-150	
28228218-10	2017	The induction of DR5 and pro-apoptotic effect were mediated through activation of ER stress accompanying by increased synthesis of GRP78 and CHOP, which can be blocked by adding of ER stress inhibitor 4-PBA.	4-phenylbutylamine	201-206	DNA damage inducible transcript 3	Homo sapiens	141-145	
31198003-13	2019	Furthermore, after 4-PBA inhibiting ERS, the expressions of GRP78, CHOP, IL-1beta, TNF-alpha, and P65 were significantly decreased ( P<0.05), and flow cytometry results showed that cell apoptotic rate in smoking group was decreased, showing significant difference compared with the non-smoking group ( P<0.05).	4-phenylbutylamine	19-24	DNA damage inducible transcript 3	Homo sapiens	67-71	
30854784-8	2019	Accordingly, the proapoptotic activity of FAM175B was significantly rescued by treatment with si-ATF4 and the CHOP inhibitor 4-PBA.	4-phenylbutylamine	125-130	DNA damage inducible transcript 3	Homo sapiens	110-114	
30654087-6	2019	The findings suggested that SiO2-NPs and mSiO2-NPs exposure increased the expression levels of two ER stress markers, e.g. BiP and CHOP, which could be inhibited by the ER stress inhibitor 4-PBA, following with decreased apoptosis rates in HPAEpiC.	4-phenylbutylamine	189-194	DNA damage inducible transcript 3	Homo sapiens	131-135	
27470132-0	2016	Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway.	4-phenylbutylamine	56-61	DNA damage inducible transcript 3	Homo sapiens	94-98	
27470132-8	2016	Treatment with 4-PBA decreased the protein and gene expression of GRP78, PERK, ATF4 and CHOP.	4-phenylbutylamine	15-20	DNA damage inducible transcript 3	Homo sapiens	88-92	
27470132-10	2016	These results indicate that 4-PBA alleviates RFP-induced injury in L02 cells via inhibition of the PERK-ATF4-CHOP pathway.	4-phenylbutylamine	28-33	DNA damage inducible transcript 3	Homo sapiens	109-113