PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33230889-6	2021	SB431542 (TGF-beta type I receptors inhibitor) abolished activin A-induced SMAD2/SMAD3 phosphorylation and integrin beta1 overexpression.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	0-8	SMAD family member 3	Homo sapiens	81-86	
35353346-10	2022	Several small molecular inhibitors are also in development and are briefly reviewed: LY364947, a pyrazole-based small molecular inhibitor of the serine-threonine kinase activity of TGFbetaRI; SB-431542, an inhibitor targeting several TGF-beta superfamily Type I activin receptor-like kinases as well as TGF-beta1-induced nuclear Smad3 localization; and galunisertib, an oral small molecular inhibitor of the TGFbetaRI kinase.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	192-201	SMAD family member 3	Homo sapiens	329-334	
35446183-14	2022	Increased IL-6 and IL-10 secretion by SB431542 along with increase in pSTAT3 and pCREB1 could probably explain these TGF-beta/Smad3 independent effects.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	38-46	SMAD family member 3	Homo sapiens	126-131	
35446183-15	2022	CONCLUSION: These results highlight that TGF-beta-pSMAD3 and TNF-alpha-pNF-kB are the predominant signaling pathways in radioresistant cells and possibility of some TGF-beta/Smad3 independent effects on prolonged treatment with the drug SB431542.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	237-245	SMAD family member 3	Homo sapiens	174-179	
33646466-9	2021	Inhibition of TGFbeta receptor-mediated signaling by SB431542 abrogated 7KC-induced loss of endothelial and increase in mesenchymal proteins in association with decreased transcription factor, SMAD3.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	53-61	SMAD family member 3	Homo sapiens	193-198	
33062456-8	2020	Further study showed that SB431542, an inhibitor of the TGF-beta/BMP signaling, significantly suppressed the mRNA expression of TGFBR3, BMP4, BMP7, BMPR1B, SMAD3, SMAD4, and the pro-proliferative effect of HA on hAECs.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	26-34	SMAD family member 3	Homo sapiens	156-161	
30543834-7	2019	Inhibition of osteoclast differentiation by TGF-beta1 was reversed by 1 muM SB431542 (an inhibitor of ALK4/5/7), which inhibited TGF-beta1-induced phosphorylation of SMAD1, but not that of SMAD3.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	76-84	SMAD family member 3	Homo sapiens	189-194	
30804470-6	2019	Cadmium exposure elevated the level of phosphorylated Smad3, and treatment with the ALK4/5 kinase inhibitors, SB431542 or SB505124, suppressed cadmium-induced HK-2 cell death.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	110-118	SMAD family member 3	Homo sapiens	54-59	
30276219-8	2018	Upregulation of Smad2/Smad3 in macrophages upon exposure to eutopic and ectopic endometrial homogenates as well as serum of women with endometriosis was observed, and blockage of Smad2/Smad3 with their inhibitor SB431542 could reverse the macrophage polarization from M1 to M2.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	212-220	SMAD family member 3	Homo sapiens	22-27	
29916554-9	2018	Inhibition of canonical TGF-beta signaling with SB431542 significantly reduced phenytoin induction of SMAD3 phosphorylation and periostin expression in HGFs.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	48-56	SMAD family member 3	Homo sapiens	102-107	
21305609-4	2011	Blockade of Smad signaling by overexpression of Smad7 or c-Ski markedly suppressed RANKL-induced osteoclastogenesis, and retroviral induction of an activated mutant of Smad2 or Smad3 reversed the inhibitory effect of SB431542.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	217-225	SMAD family member 3	Homo sapiens	177-182	
26026854-10	2015	Treatment of pbEPCs with recombinant GDF11 resulted in activation of the Smad2/Smad3 pathway and in increased migration, which was inhibited by the TGF-beta1 superfamily type-I activin receptor-like kinase inhibitor SB431542, demonstrating that the TGF-beta receptor-Smad2/Smad3 pathway is involved in GDF11 induced migration.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	216-224	SMAD family member 3	Homo sapiens	79-84	
26026854-10	2015	Treatment of pbEPCs with recombinant GDF11 resulted in activation of the Smad2/Smad3 pathway and in increased migration, which was inhibited by the TGF-beta1 superfamily type-I activin receptor-like kinase inhibitor SB431542, demonstrating that the TGF-beta receptor-Smad2/Smad3 pathway is involved in GDF11 induced migration.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	216-224	SMAD family member 3	Homo sapiens	273-278	
25707005-10	2015	Inhibition of autocrine TGF-beta signaling by either SB431542 or anti-TGF-beta antibody reduced Smad3 activation and strongly increased the number of Ki67-positive cells.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	53-61	SMAD family member 3	Homo sapiens	96-101	
24004653-7	2013	Blocking of canonical TGF-beta signaling through inhibition of the TGF-beta receptor I with SB431542 significantly reduced nifedipine-induced SMAD3 phosphorylation and periostin expression.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	92-100	SMAD family member 3	Homo sapiens	142-147	
22716253-3	2012	SB431542 and SIS3 - inhibitors of TGF-beta and Smad3, respectively - significantly alleviate alpha-NF-caused response of MMP-1 and pro-collagen.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	0-8	SMAD family member 3	Homo sapiens	47-52	
29365054-9	2018	In contrast, we used SB431542 (SB) to repress p-Smad2 and p-Smad3 expression, which resulted in a reversion of EMT.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	21-29	SMAD family member 3	Homo sapiens	60-65	
25105734-14	2014	Importantly, activin-stimulated cell invasion, up-regulation of N-cadherin, as well as activation of SMAD2/SMAD3 were abolished by the TGF-beta type I receptor inhibitor SB431542 in HTR8/SVneo cells.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	170-178	SMAD family member 3	Homo sapiens	107-112	
20604712-8	2010	Pretreatment of SB431542, a specific transforming growth factor-beta (TGF-beta) receptor type I (TbetaRI) kinase inhibitor, blocked LA-mediated Smad 2/3 phosphorylations and both type I collagen and prolyl-4-hydroxylase expression, suggesting that LA-mediated cell responses are regulated by TbetaRI kinase-dependent pathway.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	16-24	SMAD family member 3	Homo sapiens	144-152	
20129924-8	2010	Furthermore, SB-431542, an inhibitor of signaling via ALK4, ALK5, and ALK7, prevented the up-regulation of alpha11 and the concomitant phosphorylation of Smad3 under attached conditions.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	13-22	SMAD family member 3	Homo sapiens	154-159	
16735029-6	2006	Inhibition experiments using the ALK5 inhibitor SB-431542 further reveal that the transcriptional stimulation of the CSRP2 gene is mediated via the ALK5/Smad2/Smad3 signalling pathway.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	48-57	SMAD family member 3	Homo sapiens	159-164	
12065755-3	2002	We expressed the kinase domain of the TGF-beta type I receptor [activin receptor-like kinase (ALK)5] and the substrate, Smad3, and determined that SB-431542 is a selective inhibitor of Smad3 phosphorylation with an IC50 of 94 nM.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	147-156	SMAD family member 3	Homo sapiens	120-125	
12065755-3	2002	We expressed the kinase domain of the TGF-beta type I receptor [activin receptor-like kinase (ALK)5] and the substrate, Smad3, and determined that SB-431542 is a selective inhibitor of Smad3 phosphorylation with an IC50 of 94 nM.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	147-156	SMAD family member 3	Homo sapiens	185-190	
15593186-8	2004	RESULTS: SB431542 abrogated TGFbeta-induced phosphorylation and nuclear importation of endogenous Smad2/3 and Smad4, and inhibited Smad3- and Smad2-dependent gene transcription.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	9-17	SMAD family member 3	Homo sapiens	131-136