PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31645655-0	2020	Effect of CYP3A5*3 genetic variant on the metabolism of direct-acting antivirals in vitro: a different effect on asunaprevir versus daclatasvir and beclabuvir.	asunaprevir	113-124	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	10-16	
31645655-1	2020	Direct-acting antivirals, asunaprevir (ASV), daclatasvir (DCV), and beclabuvir (BCV) are known to be mainly metabolized by CYP3A enzymes; however, the differences in the detailed metabolic activities of CYP3A4 and CYP3A5 on these drugs are not well clarified.	asunaprevir	26-37	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	214-220	
31645655-1	2020	Direct-acting antivirals, asunaprevir (ASV), daclatasvir (DCV), and beclabuvir (BCV) are known to be mainly metabolized by CYP3A enzymes; however, the differences in the detailed metabolic activities of CYP3A4 and CYP3A5 on these drugs are not well clarified.	asunaprevir	39-42	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	214-220	
31645655-2	2020	The aim of the present study was to elucidate the relative contributions of CYP3A4 and CYP3A5 to the metabolism of ASV, DCV, and BCV, as well as the effect of CYP3A5*3 genetic variant in vitro.	asunaprevir	115-118	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	87-93	
31645655-5	2020	The contribution of CYP3A5 to ASV metabolism was considerable compared to that of CYP3A4.	asunaprevir	30-33	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	20-26	
31645655-6	2020	Consistently, ASV metabolic activity in CYP3A5 expressers was higher than those in CYP3A5 non-expresser.	asunaprevir	14-17	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	40-46	
31645655-7	2020	Moreover, CYP3A5 expression level was significantly correlated with ASV metabolism.	asunaprevir	68-71	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	10-16	
31645655-9	2020	To our knowledge, this is the first study to directly demonstrate the effect of CYP3A5*3 genetic variants on the metabolism of ASV.	asunaprevir	127-130	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	80-86	
26153443-12	2016	In vitro studies with human cDNA expressed CYP enzymes and with human liver microsomes (HLM) in the presence of selective chemical inhibitors demonstrated that ASV was primarily catalyzed by CYP3A4 and CYP3A5.	asunaprevir	160-163	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	202-208