PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28272477-0	2017	Chemosensitivity of MCF-7 cells to eugenol: release of cytochrome-c and lactate dehydrogenase.	Eugenol	35-42	cytochrome c, somatic	Homo sapiens	55-67	
15922856-4	2005	We observed that eugenol transduced the apoptotic signal via ROS generation, thereby inducing mitochondrial permeability transition (MPT), reducing anti-apoptotic protein bcl-2 level, inducing cytochrome c release to the cytosol, and subsequent apoptotic cell death.	Eugenol	17-24	cytochrome c, somatic	Homo sapiens	193-205	
31684176-9	2019	Eugenol increased caspase-3 activity and the expression of Bax, cytochrome c (Cyt-c), caspase-3, and caspase-9 and decreased the expression of B-cell lymphoma (Bcl)-2, cyclooxygenase-2 (Cox-2), and interleukin-1 beta (IL-1beta) indicating that eugenol mainly induced cell death by apoptosis.	Eugenol	0-7	cytochrome c, somatic	Homo sapiens	64-76	
31684176-9	2019	Eugenol increased caspase-3 activity and the expression of Bax, cytochrome c (Cyt-c), caspase-3, and caspase-9 and decreased the expression of B-cell lymphoma (Bcl)-2, cyclooxygenase-2 (Cox-2), and interleukin-1 beta (IL-1beta) indicating that eugenol mainly induced cell death by apoptosis.	Eugenol	0-7	cytochrome c, somatic	Homo sapiens	78-83	
28272477-4	2017	Eugenol demonstrated: a dose-dependent decrease in viability (MTT assay), and proliferation (real time cell analysis) of MCF-7 cells, (EC50: 0.9 mM); an increase in reactive oxygen species; a decrease in ATP level and mitochondrial membrane potential (MitoPT JC-1 assay); and a release of cytochrome-c and lactate dehydrogenase (Cytotoxicity Detection Kit PLUS) into culture media at eugenol concentration >EC50.	Eugenol	0-7	cytochrome c, somatic	Homo sapiens	289-301	
25455450-9	2015	Eugenol induced apoptosis through increasing reactive oxygen species (ROS) production, decreasing mitochondrial membrane potential, releasing cytochrome c and activating caspase-9/caspase-3.	Eugenol	0-7	cytochrome c, somatic	Homo sapiens	142-154