PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17509409-4	2007	Eugenol was shown to block the release of the bone resorbing mediators, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and prostaglandin E2 from LPS-stimulated macrophages.	Eugenol	0-7	interleukin 1 beta	Homo sapiens	82-99	
24647791-13	2015	Aspirin and eugenol enhanced the IL-1beta-induced sICAM-1 production and ICAM-1 expression.	Eugenol	12-19	interleukin 1 beta	Homo sapiens	33-41	
23422489-0	2013	Re-evaluation of anti-inflammatory potential of eugenol in IL-1beta-stimulated gingival fibroblast and pulp cells.	Eugenol	48-55	interleukin 1 beta	Homo sapiens	59-67	
23422489-2	2013	In the present study, we investigated the effect of eugenol on interleukin-8 (IL-8) production by IL-1beta-stimulated oral cells.	Eugenol	52-59	interleukin 1 beta	Homo sapiens	98-106	
21939359-9	2011	In addition, the expression analysis of genes involved in apoptosis and inflammation revealed significant downregulation of Bcl-2, COX-2, and IL-1beta on treatment with eugenol.	Eugenol	169-176	interleukin 1 beta	Homo sapiens	142-150	
17509409-4	2007	Eugenol was shown to block the release of the bone resorbing mediators, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and prostaglandin E2 from LPS-stimulated macrophages.	Eugenol	0-7	interleukin 1 beta	Homo sapiens	101-109	
17509409-6	2007	Consistent with downregulation of bone-resorbing mediators, eugenol suppressed the messenger RNA expression of LPS-induced IL-1beta, TNF-alpha, and cyclooxygenase-2 in macrophages.	Eugenol	60-67	interleukin 1 beta	Homo sapiens	123-131	
31684176-9	2019	Eugenol increased caspase-3 activity and the expression of Bax, cytochrome c (Cyt-c), caspase-3, and caspase-9 and decreased the expression of B-cell lymphoma (Bcl)-2, cyclooxygenase-2 (Cox-2), and interleukin-1 beta (IL-1beta) indicating that eugenol mainly induced cell death by apoptosis.	Eugenol	0-7	interleukin 1 beta	Homo sapiens	198-216	
31684176-9	2019	Eugenol increased caspase-3 activity and the expression of Bax, cytochrome c (Cyt-c), caspase-3, and caspase-9 and decreased the expression of B-cell lymphoma (Bcl)-2, cyclooxygenase-2 (Cox-2), and interleukin-1 beta (IL-1beta) indicating that eugenol mainly induced cell death by apoptosis.	Eugenol	0-7	interleukin 1 beta	Homo sapiens	218-226	
26960744-7	2016	Along with the lower levels of inflammatory cytokine gene expressions in the extract, treatment of the 2D IHOKs with Zn(2+) alone and treatment of the 3D IHOKs with Zn(2+) plus eugenol resulted in significantly lower expression levels of IL-1beta, IL-6, and IL-8 (P<0.05).	Eugenol	177-184	interleukin 1 beta	Homo sapiens	238-246