PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33839411-0 2021 Mode-selective inhibitory effects of eugenol on the mouse TRPV1 channel. Eugenol 37-44 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 58-63 33839411-4 2021 Eugenol is a vanilloid that has been used as an analgesic in the dental treatment, and its TRPV1 activation ability has been reported. Eugenol 0-7 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 91-96 33839411-5 2021 However, our knowledge about the underlying mechanisms of the antagonistic effects of eugenol on TRPV1 activation induced by three different modes is limited. Eugenol 86-93 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 97-102 33839411-6 2021 Here, we show that eugenol dose-dependently inhibited the capsaicin-activated inward currents of mouse TRPV1 expressed in human embryonic kidney 293 (HEK293) cells. Eugenol 19-26 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 103-108 24384226-6 2014 In addition, eugenol response was observed in trigeminal ganglion neurons from TRPV1 knockout mice and human embryonic kidney 293 cell lines that express human TRPA1, which was inhibited by TRPA1-specific antagonist HC-030031. Eugenol 13-20 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 79-84 24358880-9 2013 TRPV1 knockouts showed deficiencies in the detection of benzaldehyde, cyclohexanone and eugenol in at least one assay. Eugenol 88-95 transient receptor potential cation channel, subfamily V, member 1 Mus musculus 0-5